588732-65-4

Upstream product

• 67-56-1 methanol 
• 393860-82-7 3,5-dichloro-1-(4-methoxybenzyl)pyrazin-2(1H)-one 
• 2996-92-1 phenyl trimethylsiloxane 
• 2768-02-7 (vinyl)trimethoxylsilane 

Downstream Products

• 1015075-01-0 1-(4-methoxybenzyl)-5-chloro-3-methoxypyrazin-2-(1H)-thione 
• 1015075-23-6 2-(4-methoxybenzylthio)-5-chloro-3-methoxypyrazine 
• 1262486-35-0 5-chloro-3-methoxy-2-(4-methoxyphenyl)pyrazine 
• 1262486-36-1 5-chloro-3-methoxy-2-(3,4-dimethoxyphenyl)pyrazine 
• 1262486-37-2 5-chloro-3-methoxy-2-(3,4-difluorophenyl)pyrazine 
• 1262486-38-3 5-chloro-2-(3-(trifluoromethyl)phenyl)-3-methoxypyrazine 
• 1262486-44-1 5-ethynyl-3-methoxy-2-(4-methoxyphenyl)pyrazine 
• 1262486-48-5 (2R,3R,4R,5R)-2-(benzoyloxymethyl)-5-(4-(6-methoxy-5-(4-methoxyphenyl)pyrazin-2-yl)-1H-1,2,3-triazol-1-yl)tetrahydrofuran-3,4-diyl dibenzoate 

Relevant academic research and scientific papers

Efficient preparation of tetrasubstituted pyrazines starting from pyrazin-2(1H)-ones

An efficient methodology for the synthesis of tetrasubstituted pyrazines starting from pyrazin-2(1H)-ones has been elaborated. Diversity in the functionalization and the beneficial effect of microwave irradiation throughout the methodology has been demonstrated. Georg Thieme Verlag Stuttgart · New York.

An expeditious route toward pyrazine-containing nucleoside analogues

An improved and convenient methodology for the synthesis of asymmetrically substituted pyrazines starting from 3,5-dichloropyrazin-2(1H)-ones has been elaborated. Several nucleoside analogues have been synthesized containing the pyrazine core as the organic base coupled with the sugar via a triazole linkage. The beneficial effect of microwave irradiation throughout the sequence has been demonstrated.

Palladium-catalyzed desulfitative C-C cross-coupling reaction of (hetero)aryl thioesters and thioethers with arylsiloxanes

The first desulfitative Hiyama-type cross-coupling protocol is reported and exemplified by the synthesis of substituted 5-chloro-3-arylpyrazinones. The method has also been successfully applied for the arylation of other (hetero)aryl thioethers and thioes

A novel and versatile entry to asymmetrically substituted pyrazines

(Chemical Equation Presented) A novel and convenient procedure for the synthesis of asymmetrically tri- and tetrasubstituted pyrazines starting from para-methoxybenzyl-protected 3,5-dichloro-2(1H)-pyrazinones was elaborated. The key step is the conversion