101513-78-4

Basic information

• Product Name: 3-CHLORO-2,4,5-TRIFLUOROBENZOYL CHLORIDE
• Synonyms: 3-CHLORO-2,4,5-TRIFLUOROBENZOYL CHLORIDE;3-Chloro-2,4,5-trifluorobenzoylchloride98%;3-Chloro-2,4,5-trifluorobenzoic acid chloride
• CAS NO: 101513-78-4
• Molecular Formula: C₇HCl₂F₃O
• Molecular Weight: 228.98
• Mol File: 101513-78-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 205.782 °C at 760 mmHg
• Flash Point: 78.254 °C
• Appearance: /
• Density: 1.631 g/cm³
• Vapor Pressure: 0.246mmHg at 25°C
• Refractive Index: 1.501
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3-CHLORO-2,4,5-TRIFLUOROBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2,4,5-TRIFLUOROBENZOYL CHLORIDE(101513-78-4)
• EPA Substance Registry System: 3-CHLORO-2,4,5-TRIFLUOROBENZOYL CHLORIDE(101513-78-4)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 101513-78-4(Hazardous Substances Data)

Usage

Uses

3-Chloro-2,4,5-trifluorobenzoyl Chloride is used in preparation method of Sitafloxacin intermediate.

InChI:InChI=1/C7HCl2F3O/c8-4-5(11)2(7(9)13)1-3(10)6(4)12/h1H

Upstream product

• 119385-80-7 3-amino-2,4,5-trifluorobenzoic acid 
• 79-37-8 oxalyl dichloride 
• 101513-77-3 3-Chloro-2,4,5-trifluorobenzoic acid 

Downstream Products

• 101987-86-4 ethyl β-(3-chloro-2,4,5-trifluorophenyl)-β-oxopropionate 

Relevant articles and documents

Novel C-7 carbon substituted fourth generation fluoroquinolones targeting N. Gonorrhoeae infections

Delafloxacin, a fourth-generation anionic fluoroquinolone (FQ) was approved in 2019 for community acquired bacterial pneumonia (CARP). It has broad spectrum activity and an improved class-related toxicity profile. However, it has recently failed a Phase 3

Preparation method of Delafloxacin and intermediates thereof

The invention relates to a preparation method of Delafloxacin and intermediates thereof. The method comprises the following steps: firstly, taking 3-chloro-2,4,5-fluorobenzoic acid (compound 1) as a raw material and reacting the raw material with thionyl

Synthesis and bioactivity of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives

A series of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives was prepared and examined for cardiotonic activity. The structures of these new pyridazinone derivatives were confirmed by IR, 1H-NMR and mass spectrum. The cardiotonic activities of these compounds were studied on isolated perfused toad heart and compared with the activity of levosimendan (CAS 141505-33-1). Compound 5a emerged as the most interesting compound in this series with potential cardiotonic activity. ECV Editio Cantor Verlag.