1015255-46-5

Basic information

• Product Name: (S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid methyl ester
• Synonyms: (S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid methyl ester
• CAS NO: 1015255-46-5
• Molecular Weight: 501.405
• Mol File: 1015255-46-5.mol
• Article Data: 4

Chemical Properties

• Density: 1.46±0.1 g/cm3(Predicted)
• CAS DataBase Reference: (S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid methyl ester(1015255-46-5)
• EPA Substance Registry System: (S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy](phenoxy)phosphorylamino}propionic acid methyl ester(1015255-46-5)

Safety Data

• Hazardous Substances Data: 1015255-46-5(Hazardous Substances Data)

Usage

Uses

Sofosbuvir O-Desisopropyl O-Methyl Ester has potential utility for developing treatment for?Hepatitis C Virus.It is also an impurity of?Sofosbuvir?(P839640).

Upstream product

• 863329-66-2 2'-deoxy-2'-fluoro-2'-methyluridine 
• 142629-80-9 phenyl methoxyalaninyl phosphorochloridate 
• 770-12-7 O-phenyl phosphorodichloridate 
• 817204-32-3 (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate 
• 817204-33-4 (2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine 
• 863329-65-1 (2‘R)-2‘-deoxy-2’-fluoro-2-methyluridine-3’,5’-dibenzoate 

Relevant articles and documents

The mechanism of action of β-D-2′-deoxy-2′-fluoro- 2′-C-methylcytidine involves a second metabolic pathway leading to β-D-2′-deoxy-2′-fluoro-2′-C-methyluridine 5′-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase

β-D-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) is a potent inhibitor of hepatitis C virus (HCV) RNA replication in an HCV replicon assay. The 5′-triphosphate of PSI-6130 is a competitive inhibitor of the HCV RNA-dependent RNA polymerase (RdRp) and

NUCLEOSIDE PHOSPHORAMIDATE PRODRUGS

Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.