10153-16-9

Usage

Potential use

Pesticide for controlling the growth of insects and pests that damage crops and plants

Potential therapeutic effects

Treatment of certain cancers and infectious diseases

Structural components

+ Carbamothioyl group
+ Hydrazine group
+ Carboxamide group

Need for further research

To fully understand its biological activity and potential uses

Upstream product

• 563-41-7 semicarbazide hydrochloride 
• 103-72-0 phenyl isothiocyanate 
• 53678-38-9 N,N'-dicarbamoyl-N,N'-diisothiocyanato-thiourea 
• 62-53-3 aniline 
• 855185-43-2 1,5-bis-ethoxythiocarbonyl-2,4-dicarbamoyl-thio carbonohydrazide 
• 1438-18-2 3-ureidothiazolidine-2-thion-4-one 
• 64-17-5 ethanol 
• 7732-18-5 water 

Downstream Products

• 861515-33-5 1-carbamoyl-S-methyl-4-phenyl-iso thiosemicarbazide 
• 7746-66-9 5-methylthio-4-phenyl-1H<1,2,4>triazole-3(4H)-one 
• 27106-12-3 4-phenyl-5-thioxo-[1,2,4]triazolidin-3-one 

Relevant academic research and scientific papers

Heterocyclization of 1-aryl/alkyl-2-thiobiureas to 4-aryl/alkyl-3-substituted-Δ2-1,2,4-triazolin-5-ones

Synthesis of a range of 1,2,4-triazolin-5-ones has been carried out by thermally induced cyclization of 1-aryl/alkyl-2-alkyl isothiobiureas 4. The required isothiobiureas were generated in situ by the reaction of alkyl halides with 1-aryl/alkyl-2-thiobiureas 3 in acidic medium at reflux. The reaction proceeds after S-alkylation of the thiobiureas and is demonstrated by the isolation of the alkyl isothiobiurea intermediates and their subsequent acid catalyzed thermal cyclization.

SYNTHESIS AND REACTIONS OF 3-AMINOTHIAZOLIDINE-2-THION-4-ONE DERIVATIVES. 1. CONVERSION OF 3-AMINOTHIAZOLIDINE-2-THION-4-ONE DERIVATIVES TO SUBSTITUTED MERCAPTO-1,3,4-THIADIAZOLES

The corresponding carboxymethylthiothiadiazoles are formed by the action of formic acid on 3-aminorhodanine and 3-(3-phenylthioureido)rhodanine, and the action of rhodanineaniline on 3-(3-phenylthioureido)rhodanine leads to 2-anilino-5-carboxymethylthioth