27106-12-3

Usage

Uses

Used in Pharmaceutical Industry:
5-Mercapto-4-phenyl-4H-1,2,4-triazol-3-ol is used as a pharmaceutical agent for its potential antioxidant and antitumor activities. It is being studied for its ability to combat oxidative stress and inhibit tumor growth, making it a promising candidate for the development of treatments for various cancers.
Used in Enzyme Inhibition:
In the field of biochemistry, 5-mercapto-4-phenyl-4H-1,2,4-triazol-3-ol is used as an enzyme inhibitor. Its capacity to inhibit the activity of certain enzymes suggests potential applications in modulating biological processes and developing treatments for enzyme-related diseases.
Used in Organic Synthesis:
5-Mercapto-4-phenyl-4H-1,2,4-triazol-3-ol is utilized as a building block in organic synthesis. Its unique structure allows it to be incorporated into the design and synthesis of more complex organic compounds and materials, which can be applied across various industries, including pharmaceuticals, materials science, and chemical research.

InChI:InChI=1/C8H7N3OS/c12-7-9-10-8(13)11(7)6-4-2-1-3-5-6/h1-5H,(H,9,12)(H,10,13)

Upstream product

• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 57-13-6 urea 
• 105-58-8 Diethyl carbonate 
• 134832-81-8 C₁₅H₁₅N₃OS₂ 
• 103-72-0 phenyl isothiocyanate 
• 103557-05-7 2-(anilinothioformyl)hydrazine-1-carboxylic acid methyl ester 
• 62-53-3 aniline 
• 38110-48-4 3-phenylthiocarbamoyl-carbazic acid ethyl ester 
• 10153-16-9 1-phenylthiocarbamoylsemicarbazide 

Downstream Products

• 7746-66-9 5-methylthio-4-phenyl-1H<1,2,4>triazole-3(4H)-one 
• 51039-72-6 2-methyl-5-methylsulfanyl-4-phenyl-2,4-dihydro-[1,2,4]triazol-3-one 
• 7746-65-8 5-benzylsulfanyl-4-phenyl-2,4-dihydro-[1,2,4]triazol-3-one 
• 186371-10-8 BI-83C₉ 
• 7746-66-9 5‐methylthio‐4‐phenyl‐4H‐1,2,4‐triazol‐3‐ol 
• 7746-65-8 5-(benzylsulfanyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1064664-59-0 5-(ethylsulfanyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1064664-72-7 5-(5-nitrothiophen-2-ylthio)-4-phenyl-4H-1,2,4-triazol-3-ol 
• 1064664-59-0 5-(ethylthio)-4-phenyl-4H-1,2,4-triazol-3-ol 

Relevant academic research and scientific papers

Preparation method of 3-thio-1, 2, 4-triazole compound

The invention provides a preparation method of a 3-thio-1, 2, 4-triazole compound shown as formula I. The method includes the step of: reacting a compound shown as formula II with a compound shown asformula III to obtain the compound shown as formula I in

Synthesis and evaluation of the anticonvulsant activity of 5-alkylthio-4-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one derivatives

A new series of 5-alkylthio-4-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one derivatives (4a-w) have been synthesized and tested for their anticonvulsant activity using the maximal electroshock (MES) test. The results indicated that all of the target compounds

Domino synthesis of novel series of 4-substituted 5-thioxo-1,2,4- triazolidin-3-one derivatives

The efficient synthesis of 4-substituted 5-thioxo-1,2,4-triazolidin-3-one derivatives (4-substituted thiourazoles) via domino combination of thiophosgene, aliphatic or aromatic amines, and ethyl carbazate is presented.

Thiocarbazinic acids: Interaction of carbonoxysulphide with thiosemicarbazides - Synthesis of &β-(thiocarbamyl)thiocarbazinates and 1,3,4-oxadiazole and 1,2,4-triazole derivatives

Interaction of carbon oxysulphide with 4-alkyl/arylthiosemicarbazides (I) in ethanol in the presence of sodium hydroxide forms sodium β-(N-alkyl/arylthiocarbamyl)thiocarbazinates (II).Benzylation of the latter (II) affords 5-alkyl/arylamino-2-benzylmercapto-1,3,4-oxadiazoles (IV), which can also be obtained by a one-pot synthesis involving the reaction of I with carbon oxysulphide in DMF in the presence of triethylamine and benzyl chloride.The syntheses of benzyl β-(N-alkyl/arylthiocarbamyl)thiocarbazinates (III) and 4-aryl-3-mercapto-1,2,4-triazolin-5-ones (VII) are also reported.Some of the compounds exhibit antibacterial activity.