1015414-83-1Relevant articles and documents
N-heterocyclic carbene-catalyzed nucleophilic aroylation of fluorobenzenes
Suzuki, Yumiko,Ota, Shinya,Fukuta, Yoshinori,Ueda, Yuki,Sato, Masayuki
, p. 2420 - 2423 (2008/09/19)
(Chemical Equation Presented) In N-heterocyclic carbene (NHCs) catalyzed nucleophilic substitution of fluorobenzenes, fluoro groups are replaced by aroyl groups, which are derived from aromatic aldehydes. 1,3,4,5-Tetramethylimidazol- 2-ylidene is found to be an efficient catalyst. The catalyst loading can be reduced to 1 mol % without a significant decrease in the product yields. Polysubstituted benzophenones are synthesized from fluorobenzenes and benzaldehydes by the NHC-catalyzed aroylation.