10155-19-8

Basic information

• Product Name: 2-(isopropyl(phenyl)amino)acetonitrile
• Synonyms: 2-(isopropyl(phenyl)amino)acetonitrile
• CAS NO: 10155-19-8
• Molecular Weight: 174.246
• Mol File: 10155-19-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(isopropyl(phenyl)amino)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(isopropyl(phenyl)amino)acetonitrile(10155-19-8)
• EPA Substance Registry System: 2-(isopropyl(phenyl)amino)acetonitrile(10155-19-8)

Safety Data

• Hazardous Substances Data: 10155-19-8(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 52008-97-6 N-isopropyl-N-phenylformamide 
• 768-52-5 N-Isopropylaniline 
• 372-09-8 cyanoacetic acid 

Relevant articles and documents

Iron-catalyzed reductive strecker reaction

Strecker reaction is widely applied for the synthesis of amino acids from aldehydes, amines and cyanides. Herein, we report the FeI2-catalyzed reductive Strecker type reaction of formamides instead of aldehydes to produce amino acetonitriles. The challenging capture of carbinolamine intermediates by CN? was achieved via Fe catalysis. This approach afforded better yields than the use of Ir- or Rh-catalysts. The application ability of this methodology is demonstrated by 1) one-pot construction of (13C labeled) complex molecules from CO2 via amino acetonitrile intermediates and 2) convenient production of homologated carboxylic acids from aldehydes.

Cyanoacetic Acid as a Masked Electrophile: Transition-Metal-Free Cyanomethylation of Amines and Carboxylic Acids

Using cyanoacetic acid as a masked electrophile, a new cyanomethylation reaction of amines and carboxylic acids was developed, producing a variety of α-aminonitriles and cyanomethyl esters with good yields and excellent functionality tolerance. This protocol features simple manipulation, inexpensive reagents, and a wide substrate scope. Iodoacetonitrile was generated in situ from the iodination-decarboxylation of cyanoacetic acid in this transformation.