101565-57-5Relevant articles and documents
Regioselective 1-N-Alkylation and rearrangement of adenosine derivatives
Oslovsky, Vladimir E.,Drenichev, Mikhail S.,Mikhailov, Sergey N.
, p. 475 - 499 (2015)
Several methods for the preparation of some N6-substituted adenosines based on selective 1-N-alkylation with subsequent Dimroth rearrangement were developed. The proposed methods seem to be effective for the preparation of natural N6-isopentenyl- and N6-benzyladenosines, which are known to possess pronounced biological activities. Direct 1-N-alkylation of 2′,3′,5′-tri-O-acetyladenosine and 3,5′-di-O-acetyl-2-deoxyadenosine with alkyl halides in N,N-dimethylformamide (DMF) in the presence of BaCO3 and KI gave 1-N-substituted derivatives with quantitative yields, whereas 1-N-alkylation of adenosine was accompanied by significant O-alkylation. Moreover, the reaction of trimethylsilyl derivatives of N6-acetyl-2,3,5′-tri-O-acetyladenosine and N6-acetyl-3,5′-di-O-acetyl-2-deoxyadenosine with alkyl halides leads to the formation of the stable 1-N-substituted adenosines. Dimroth rearrangement of 1-N-substituted adenosines in aqueous ammonia yields pure N6-substituted adenosines.
Anti-HCV nucleoside derivatives
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, (2008/06/13)
The present invention comprises novel and known purine and pyrimidine nucleoside derivatives which have been discovered to be active against hepatitis C virus (HCV). The use of these derivatives for the treatment of HCV infection is claimed as are the novel nucleoside derivatives disclosed herein.
Alternating dependency of cytokinin activity in the number of methylene units in ω-phenylalkyl derivatives of some purine cytokinins and 4-substituted pyrido[3,4-d]pyrimidine.
Nishikawa, Shiro,Kumazawa, Zenzaburo,Kashimura, Naoki,Nishimiki, Yoshio,Uemura, Shoji
, p. 2243 - 2250 (2007/10/02)
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