3742-75-4

Upstream product

• 122-97-4 3-Phenyl-1-propanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 14629-60-8 trimethyl(3-phenylpropoxy)silane 
• 455-16-3 p-toluenesulfonyl fluoride 
• 4124-41-8 p-toluenesulfonylanhydride 
• 2290-40-6 3-phenylpropanol triethylsilyl ether 
• 69404-95-1 tert-butyldimethyl(3-phenylpropoxy)silane 
• 69804-99-5 3-phenylpropanol methanesulfonate 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 1199-99-1 N,N-dimethyl-3-phenylpropylamine 
• 103-65-1 phenylpropane 
• 873-49-4 cyclopropylbenzene 
• 72444-53-2 4-Ethyl-benzenesulfonic acid 3-phenyl-propyl ester 
• 122-97-4 3-Phenyl-1-propanol 
• 136534-76-4 N-(2-phenylethyl)-3-phenylpropylamine 
• 1078-71-3 heptylbenzene 
• 2046-18-6 4-phenylbutyronitrile 
• 4119-41-9 1-iodo-3-phenylpropan 
• 43008-84-0 3-phenyl-1-(4-fluorophenyl)propane 
• 917107-63-2 (η5-cyclopentadienyl)(carbonyl)3Mo(CH2)3Ph 
• 1010447-25-2 (pent-4-ynyl)(3-phenylpropyl)sulfane 
• 1138320-44-1 N'-phenylhydrazinecarbodithioic acid 3-phenylpropyl ester 
• 1081-75-0 1,3-diphenylpropane 

Relevant academic research and scientific papers

Nickel-Catalyzed Decarboxylative Coupling of Redox-Active Esters with Aliphatic Aldehydes

The addition of alkyl fragments to aliphatic aldehydes is a highly desirable transformation for fragment couplings, yet existing methods come with operational challenges related to the basicity and instability of the nucleophilic reagents commonly employed. We report herein that nickel catalysis using a readily available bioxazoline (BiOx) ligand can catalyze the reductive coupling of redox-active esters with aliphatic aldehydes using zinc metal as the reducing agent to deliver silyl-protected secondary alcohols. This protocol is operationally simple, proceeds under mild conditions, and tolerates a variety of functional groups. Initial mechanistic studies suggest a radical chain pathway. Additionally, alkyl tosylates and epoxides are suitable alkyl precursors to this transformation providing a versatile suite of catalytic reactions for the functionalization of aliphatic aldehydes.

Electron Donor-Acceptor Complex Enabled Decarboxylative Sulfonylation of Cinnamic Acids under Visible-Light Irradiation

Visible-light-induced decarboxylative sulfonylation of cinnamic acids with aryl sulfonate phenol esters enabled by the electron donor-acceptor complex is developed. The method offers a mild and green approach for the synthesis of vinyl sulfones with excellent functional group compatibility under photocatalyst and oxidant-free conditions.

Manganese-Catalyzed Stereospecific Hydroxymethylation of Alkyl Tosylates

The development of a stereospecific hydroxymethylation of alkyl tosylates using an inexpensive, first-row catalyst is described. The transformation proceeds under mild conditions with low pressure to deliver homologated alcohols as products. Chiral, nonracemic β-branched primary alcohols are obtained with high enantiospecificity from easily accessed secondary alkyl substrates. Simple modification of the reaction system also permits access to α-d2 alcohols. These studies use anionic metal carbonyl catalysis to access a synthetic equivalent of the challenging hydroxymethyl anion from carbon monoxide.

PHOSPHONIUM COMPOUND AND PRODUCTION METHOD THEREFOR

The present invention provides a phosphonium compound of formula (II). Also provided is a method for producing a quaternary phosphonium compound labeled with a positron emitting radionuclide, the method comprising the step of reacting an electrophile of f

Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

A novel strategy for the production of reactive [18F]fluoride has been developed, omitting time consuming azeotropic drying procedures. Gaseous [18F]triflyl fluoride is formed instantaneously at room temperature from hydrated [18F]fluoride, followed by distillation in less than 5 minutes into a dry aprotic solvent, in which dry [18F]fluoride is released in presence of base with >90% radiochemical yield. The reactivity of the [18F]fluoride has been confirmed by reaction with several model compounds and by the synthesis of the PET tracers [18F]fluoroestradiol ([18F]FES) and O-2-[18F]fluoroethyl-l-tyrosine ([18F]FET), providing good isolated radiochemical yields and molar activities of up to 123 GBq μmol?1.

ABSCISIC ACID DERIVATIVE

The compound represented by formula (IV) or a salt thereof has an inhibitory action on an abscisic acid receptor. The compound or the salt thereof can be used as a plant growth regulator. wherein X is an ethylene group, an ethenylene group or an ethynyle

Molybdenum oxide-mediated facile aliphatic nucleophilic fluorination

A facile aliphatic nucleophilic fluorination with cesium fluoride in the presence of molybdenum oxide as a catalyst has been demonstrated. Reactivity of molybdenum oxide in nanocrystal form was found to be chemoselective in the presence of water. Furthermore, the reaction is highly specific with alkyl sulfonate substrates.

METAL OXIDE CATALYZED RADIOFLUORINATION

Inter alia, the first titania-catalyzed [18F]-radiofluorination in highly aqueous medium is provided. In embodiments, the method utilizes titanium dioxide, 1 : 1 acetonitrile- thexyl alcohol solvent mixture and tetrabutylammonium bicarbonate as a base. Radiolabeling may be directly performed with aqueous [18F]fluoride without the need for drying/azeotroping step, which reduces radiosynthesis time while keeping high fluoride conversion. The general applicability of the synthetic strategy to the synthesis of the wide range of PET probes from tosylated precursors is demonstrated.

Titania-catalyzed radiofluorination of tosylated precursors in highly aqueous medium

Nucleophilic radiofluorination is an efficient synthetic route to many positron-emission tomography (PET) probes, but removal of water to activate the cyclotron-produced [18F]fluoride has to be performed prior to reaction, which significantly increases overall radiolabeling time and causes radioactivity loss. In this report, we demonstrate the possibility of 18F-radiofluorination in highly aqueous medium. The method utilizes titania nanoparticles, 1:1 (v/v) acetonitrile-thexyl alcohol solvent mixture, and tetra-n-butylammonium bicarbonate as a phase-transfer agent. Efficient radiolabeling is directly performed with aqueous [18F]fluoride without the need for a drying/azeotroping step to significantly reduce radiosynthesis time. High radiochemical purity of the target compound is also achieved. The substrate scope of the synthetic strategy is demonstrated with a range of aromatic, aliphatic, and cycloaliphatic tosylated precursors.

A dicationic, podand-like, ionic liquid water system accelerated copper-catalyzed azide-alkyne click reaction

In this work, an effective, task specific, dicationic, podand-like ionic liquid was synthesized and applied to improve the capability features of click reaction. Moreover, to broaden the scope and decreasing the serious limitations of preparation methods of organic azides, a simple green procedure for the preparation of alkyl azides, the fundamental starting materials in click reactions, from alcohols under solvent-free conditions and microwave irradiation has been reported, for the first time.