1015770-33-8Relevant articles and documents
Hydrazidohydroxylation of styrenes with N-acetylaminophthalimide using phenyliodine(III) bis(trifluoroacetate) (PIFA)
Murata, Kousuke,Tsukamoto, Masato,Sakamoto, Takeshi,Saito, Setsuo,Kikugawa, Yasuo
, p. 32 - 38 (2008/09/19)
Regioselective hydrazidohydroxylation of styrenes with N- acetylaminophthalimide using phenyliodine(III) bis(trifluoroacetate) was carried out to afford 1-aryl-2-(N-acetyl-N-phthalimido)aminoethyl trifluoroacetates in high yields. The procedure is operationally simple and removal of trifluoroacetyl and phthalimido groups was performed by treatment of the trifluoroacetate with hydrazine hydrate in good yield. A synthetic study and a mechanistic proposal for the hydrazidohydroxylation are presented. Georg Thieme Verlag Stuttgart.