16067-88-2

Basic information

• Product Name: N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
• CAS NO: 16067-88-2
• Molecular Formula: C₁₀H₈N₂O₃
• Molecular Weight: 204.1821
• Mol File: 16067-88-2.mol
• Article Data: 2

Chemical Properties

• Density: 1.43g/cm³
• Refractive Index: 1.637
• CAS DataBase Reference: N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide(16067-88-2)
• EPA Substance Registry System: N-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide(16067-88-2)

Safety Data

• Hazardous Substances Data: 16067-88-2(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 1068-57-1 acetic acid hydrazide 

Downstream Products

• 1068-57-1 acetic acid hydrazide 
• 287729-08-2 N-benzyl-N-acetylaminophthalimide 
• 1403251-35-3 N-(4-chlorophenyl)-N-(1,3-dioxoisoindolin-2-yl)acetamide 
• 1015770-21-4 N-(1,3-dioxoisoindolin-2-yl)-N-(2-phenylallyl)acetamide 
• 1015770-41-8 N-(1,3-dioxoisoindolin-2-yl)-N-(4-iodophenyl)acetamide 
• 1015770-33-8 methyl 4-{2-[N-(1,3-dioxoisoindolin-2-yl)acetamido]-1-hydroxyethyl}benzoate 
• 1015770-19-0 methyl 4-{2-[N-(1,3-dioxoisoindolin-2-yl)acetamido]-1-(2,2,2-trifluoroacetoxy)ethyl}benzoate 
• 1015770-07-6 1-(2-chlorophenyl)-2-[N-(1,3-dioxoisoindolin-2-yl)acetamido]ethyl 2,2,2-trifluoroacetate 
• 1015770-09-8 1-(3-chlorophenyl)-2-[N-(1,3-dioxoisoindolin-2-yl)acetamido]ethyl 2,2,2-trifluoroacetate 
• 1015770-13-4 2-[N-(1,3-dioxoisoindolin-2-yl)acetamido]-1-o-tolylethyl 2,2,2-trifluoroacetate 
• 1015770-23-6 2-[N-(1,3-dioxoisoindolin-2-yl)acetamido]-1-phenylpropyl 2,2,2-trifluoroacetate 
• 1015770-25-8 1-[N-(1,3-dioxoisoindolin-2-yl)acetamido]-1-phenylpropan-2-yl 2,2,2-trifluoroacetate 
• 1015770-15-6 2-[N-(1,3-dioxoisoindolin-2-yl)acetamido]-1-m-tolylethyl 2,2,2-trifluoroacetate 
• 1015770-17-8 2-[N-(1,3-dioxoisoindolin-2-yl)acetamido]-1-p-tolylethyl 2,2,2-trifluoroacetate 

Relevant articles and documents

Preparation of Multiply Protected Alkylhydrazine Derivatives by Mitsunobu and PTC Approaches

Alkylation reactions of hydrazine derivatives by Mitsunobu or PTC approaches are described. It has been shown that aminophthalimide derivatives are better acidic partners than their aminoimidodicarbonate (NBoc2) analogues, the presence of the phthaloyl group increasing the acidity of the sole proton and concomitantly reducing steric hindrance. Moreover, N-aminophthalimide derivatives can be efficiently converted into the corresponding N-amino-imidodicarbonates by a three-stage, one-flask procedure under very mild conditions. These procedures can also be efficiently used for the preparation of orthogonally Nα,Nβ -diprotected α-hydrazino esters. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).