1015862-36-8

Basic information

• Product Name: 1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile
• Synonyms: 1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile
• CAS NO: 1015862-36-8
• Molecular Formula: C₁₀H₆FN₃
• Molecular Weight: 187.1731432
• Mol File: 1015862-36-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 168.0-169.0℃
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile(1015862-36-8)
• EPA Substance Registry System: 1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile(1015862-36-8)

Safety Data

• Hazardous Substances Data: 1015862-36-8(Hazardous Substances Data)

Usage

General Description

1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, also known as PF-04937319, is a chemical compound with the molecular formula C10H6N4F. It is a potent and selective inhibitor of the transient receptor potential cation channel subfamily M member 8 (TRPM8), which is a promising target for the treatment of various pain and sensory disorders. PF-04937319 has been studied for its potential use in the treatment of neuropathic pain, migraine, and other sensory-related conditions. It acts by specifically blocking the TRPM8 channel, which is involved in the sensation of cold and pain, and has shown promising results in preclinical studies as a potential therapeutic agent. Further research is ongoing to explore its potential clinical applications.

Upstream product

• 890652-03-6 1-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde 
• 81329-32-0 1-(4-fluorophenyl)-1H-pyrazole 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 51516-70-2 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile 

Downstream Products

• 1431459-41-4 5-[1-(4-fluorophenyl)-1H-pyrazole-4-yl]-1H-tetrazole 

Relevant articles and documents

Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks

Hybrid systems containing pyrazole moiety show a wide spectrum of biological activities. To access novel hybrids with pyrazole ring, in this work we synthesized twenty pyrazole-carboxylic acids and twenty pyrazole-carboxamides, using simple synthetic methods, to be used as building blocks in the development of new structures.

Flow hydrodediazoniation of aromatic heterocycles

Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles, confirming the wide scope and substituent-tolerance of the processes. Flow equipment was utilized and the process optimised to overcome the problematically-unstable intermediates that have restricted yields in previous studies relying on batch procedures. Various common organic solvents were investigated as potential hydride sources. The approach has allowed key structures, such as amino-pyrazoles and aminopyridines, to be deaminated in good yield using a purely organic-soluble system.

An efficient synthesis of new 5-(1-Aryl-1H-pyrazole-4-yl)-1H-tetrazoles from 1-Aryl-1H-pyrazole-4-carbonitriles via [3 + 2] cycloaddition reaction

A series of new 5-(1-aryl-1H-pyrazole-4-yl)-1H-tetrazoles 4a-l were synthesized via [3 + 2] cycloaddition reaction from 1-aryl-1H-pyrazole-4- carbonitriles 3a-l, sodium azide and ammonium chloride, using dimethylformamide (DMF) as solvent, in good yields: 64-85%. The structures of these newly synthesized compounds were determined from the IR, 1H- and 13C-NMR spectroscopic data and elemental analyses.