51516-70-2

Basic information

• Product Name: 5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE
• Synonyms: TIMTEC-BB SBB000407;BUTTPARK 51\09-64;AKOS B029474;5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE;5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE;5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole;5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole 97%;5-Amino-4-cyano-1-(4-fluorophenyl)-1H-pyrazole97%
• CAS NO: 51516-70-2
• Molecular Formula: C₁₀H₇FN₄
• Molecular Weight: 202.19
• Mol File: 51516-70-2.mol
• Article Data: 28

Chemical Properties

• Melting Point: 164-165°C
• Boiling Point: 394.1 °C at 760 mmHg
• Flash Point: 192.1 °C
• Appearance: /
• Density: 1.36 g/cm³
• Vapor Pressure: 2.03E-06mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.92±0.10(Predicted)
• CAS DataBase Reference: 5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE(51516-70-2)
• EPA Substance Registry System: 5-AMINO-4-CYANO-1-(4-FLUOROPHENYL)PYRAZOLE(51516-70-2)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-41
• Safety Statements: 22-36/37/39-39-26
• RIDADR: 3439
• WGK Germany: 3
• Hazardous Substances Data: 51516-70-2(Hazardous Substances Data)

Usage

General Description

5-Amino-4-cyano-1-(4-fluorophenyl)pyrazole is a chemical compound that belongs to the pyrazole class of compounds, which are known for their diverse biological and pharmacological activities. This specific compound has a molecular structure consisting of a pyrazole ring with an amino group and a cyano group attached, as well as a fluorophenyl substituent. It is commonly used in the pharmaceutical industry for the synthesis of various drugs and bioactive compounds due to its potential as a building block for more complex molecules. Additionally, it may exhibit unique biological properties and may be studied for its potential applications in drug discovery and development. However, it is important to handle this chemical with caution and ensure proper safety measures are in place due to its potential reactivity and toxicity.

InChI:InChI=1/C10H7FN4/c11-8-1-3-9(4-2-8)15-10(13)7(5-12)6-14-15/h1-4,6H,13H2

Upstream product

• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 123-06-8 Ethoxymethylenemalononitrile 
• 86240-43-9 (ethoxymethylene)malononitrile 
• 371-14-2 4-fluorophenylhydrazine 
• 672-81-1 2-(methoxymethylene)malononitrile 
• 371-40-4 4-fluoroaniline 
• 122-51-0 orthoformic acid triethyl ester 
• 109-77-3 malononitrile 

Downstream Products

• 289651-72-5 1-benzyl-5-(2,2-diethoxyethyl)-1H-pyrazolo-[3,4-d]pyrimidin-4(5H)-one 

Relevant articles and documents

Piperidine compound and preparation method and medical application thereof

The invention discloses a piperidine compound shown as a formula (I) and a preparation method and medical application thereof, and particularly relates to a piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof and a preparation method and application of the piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof. The compound provided by the invention can inhibit the activity of USP7 enzyme, has very good selectivity and druggability, and can be used for preparing medicines for preventing or treating tumor diseases or virus infectious diseases.

Microwave-assisted efficient synthesis of pyrazole-fibrate derivatives as stimulators of glucose uptake in skeletal muscle cells

The design and synthesis of a series of pyrazolo[3,4-d]pyrimidinones containing fibrate side chains have been accomplished by utilizing the concept of molecular hybridization. All the synthesized compounds were evaluated for the glucose uptake stimulatory effect in L6 rat skeletal muscle cells. Four compounds (3f, 3g, 3j and 3q) were found to show significant stimulation of glucose uptake. Further these four compounds have been examined for their Glut4 translocation stimulatory effect in L6-Glut4myc myotubes. Compound 3q was found to exert maximum increase in GLUT4myc translocation.

Discovery of novel multi-substituted benzo-indole pyrazole schiff base derivatives with antibacterial activity targeting DNA gyrase

The design and synthesis of novel multi-substituted benzo-indole pyrazole Schiff base derivatives of potent DNA gyrase inhibitory activity were the main aims of this study. All the novel synthesized compounds were examined for their antibacterial activities against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, and Salmonella. In addition, we selected 20 compounds for the in vitro antibacterial activities assay of 6 drug-resistant bacteria strains. The result revealed compound 8I-w exhibited excellent antibacterial activity against 4 drug-resistant E. coli bacteria strains with IC50 values of 7.0, 17.0, 13.5, and 1.0 μM, respectively. In vitro enzyme inhibitory assay showed that compound 8I-w displayed potent inhibition against DNA gyrase with IC50 values of 0.10 μM. The molecular docking model indicated that compounds 8I-w can bind well to the DNA gyrase by interacting with various amino acid residues. This study demonstrated that the compound 8I-w can act as the most potent DNA gyrase inhibitor in the reported series of compounds and provide valuable information for the commercial DNA gyrase inhibiting bactericides.