101601-61-0

Upstream product

• 27052-11-5 2-(4-nitrophenylimino)thiazolidin-4-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 3696-22-8 p-nitrophenylthiourea 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 847021-13-0 2-(2-{5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-2-[(E)-4-nitro-phenylimino]-4-oxo-thiazolidin-3-yl}-ethoxy)-isoindole-1,3-dione 
• 847021-40-3 7-(4-methoxy-phenyl)-2-(4-nitro-phenylimino)-2,3-dihydro-thiazolo[4,5-d]pyrimidin-5-ol 
• 847021-31-2 2-(4-{5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-2-[(E)-4-nitro-phenylimino]-4-oxo-thiazolidin-3-yl}-butoxy)-isoindole-1,3-dione 
• 847021-22-1 2-(3-{5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-2-[(E)-4-nitro-phenylimino]-4-oxo-thiazolidin-3-yl}-propoxy)-isoindole-1,3-dione 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 7-N-(n-alkoxyphthalimido)-2hydroxy- 4-aryl-6-aryliminothiazolidino [2,3-b] pyrimidines and related compounds

Substituted aryl thioureas 1a-c react with chloroacetic acid in the presence of anhydrous sodium acetate to furnish 2-aryliminothiazolidin-4-ones 2a-c. Condensation of ω-bromoalkoxyphthalimides 3a-c with 2a-c give the corresponding alkoxyphthalimide derivatives of 2-aryliminothiazolidin-4-ones 4a-i. These on condensation with araldehydes 5a-c yield 3-N-(alkoxyphthalimido)- 5-arylidene-2-aryliminothiazolidin-4-ones 7a-a′. In an alternative route 5a-c react with 2a-c to give 6a-i, which could be cyclised with urea in the presence of sodium acetate to yield the corresponding thiazolidinopyrimidine 8a-i. 7a-a′ are also prepared from 6a-i with 3a-c, which give final compound 9a-a′ on cyclisation. Alternatively, 8a-i when condensed with 3a-c also furnish the compounds 9a-a′. Evaluation of antimalarial and antibacterial activity is also reported.