101615-36-5

Upstream product

• 148043-73-6 4,4,5,5,5-pentafluorpentan-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 209325-64-4 4,4,5,5,5-pentafluoropentyl-4-methylbenzene sulphonate 
• 17356-08-0 thiourea 

Downstream Products

• 1019971-32-4 (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-3-(N-[7-(4,4,5,5,5-pentafluoropentylthio)heptyl]-N-methyl-amino)-propanamide 
• 1019972-74-7 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-11-(4,4,5,5,5-pentafluoropentylthio)undecanamide 
• 1332392-73-0 (4-(benzyloxy)butyl)(4,4,5,5,5-pentafluoropentyl)sulfane 
• 511545-94-1 9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl alcohol 

Relevant academic research and scientific papers

Fulvestrant side chain intermediate synthetic method (by machine translation)

The invention relates to a preparation method of fulvestrant side chain intermediates, in particular with five fluorine amyl alcohols in the molecular sieve to the load on the toluene sulfonic acid by the reaction of the five fluorine amyl alcohol tosylates, five fluorine amyl alcohols tosylates in ethanol with the thiourea obtained by the reaction of 4, 4, 5, 5, 5 - pentafluoropropane amyl isothiourea methanesulfonate. The invention avoids the use of acyl chloride, the production process is optimized, thus increasing the reaction yield, and reduces the environmental pollution. (by machine translation)

AMIDE DERIVATIVES

The invention concerns amide compounds of Formula (I) wherein groups R1, R2, R3, Q1, X, R4, R5, R6, and R7 are as defined in the description. The present invention als