1016161-80-0Relevant articles and documents
Systemic optimization and structural evaluation of quinoline derivatives as transthyretin amyloidogenesis inhibitors
Kim, Boyoung,Park, Hwanggue,Lee, Seul Ki,Park, Sung Jean,Koo, Tae-Sung,Kang, Nam Sook,Hong, Ki Bum,Choi, Sungwook
, p. 777 - 787 (2016)
Wild type transthyretin (TTR) and mutant TTR misfold and misassemble into a variety of extracellular insoluble amyloid fibril and/or amorphous aggregate, which are associated with a variety of human amyloid diseases. To develop potent TTR amyloidogenesis