1016169-06-4Relevant academic research and scientific papers
Synthesis of trans-fused tetrahydrooxepins: stereoselective allylation of sulfur or fluoro-substituted tetrahydrooxepins
Kobayashi, Shoji,Hori, Makiko,Hirama, Masahiro
, p. 443 - 452 (2008)
An efficient route to the trans-fused tetrahydrooxepin corresponding to the E ring of ciguatoxin was developed. Wide screening of allylation reactions of sulfur or fluoro-substituted tetrahydrooxepin revealed that the optimum method for obtaining the β-allylation product selectively was the use of a combination of allyltrimethylsilane and TiCl4 with 6-fluoro-7-hydroxytetrahydrooxepin.
