1016169-45-1Relevant academic research and scientific papers
Base-mediated reaction of hydrazones and nitroolefins with a reversed regioselectivity: A novel synthesis of 1,3,4-Trisubstituted pyrazoles
Deng, Xiaohu,Mani, Neelakandha S.
supporting information; body text, p. 1307 - 1310 (2009/04/06)
A regioselective synthesis of 1,3,4-tri- or 1,3,4,5-tetrasubstituted pyrazoles by the reaction of hydrazones with nitroolefins is described. Mediated with strong bases such as t-Bu OK, the reaction exhibits a reversed, exclusive 1,3,4-regioselectivity. Su
A facile and regioselective synthesis of rimonabant through an enamine-directed 1,3-dipolar cycloaddition
Donohue, Sean R.,Halldin, Christer,Pike, Victor W.
, p. 2789 - 2791 (2008/09/19)
Rimonabant is a high-potency cannabinoid type-1 (CB1) receptor inverse agonist that has recently been approved in the European Union as a treatment for obesity. Current methods of synthesis require several steps that have long reaction times and/or lack regioselectivity. Here we present a novel, regioselective synthesis of rimonabant though an enamine-directed 1,3-dipolar cycloaddition. In addition, we present a new and more reactive hydrazonoyl halide for the generation of the requisite nitrile imine dipole.
