1016170-85-6Relevant articles and documents
Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity
Mahindroo, Neeraj,Punchihewa, Chandanamali,Bail, Allison M.,Fujii, Naoaki
, p. 946 - 949 (2008/09/20)
We designed and synthesized a series of indole-2-amide-based compounds that antagonize interaction between the Dishevelled (Dvl) PDZ domain and a peptide derived from the natural PDZ ligand Frizzled-7 (Fz7). These compounds inhibit Tcf-mediated transcript