10164-73-5 Usage
General Description
9BETA,11ALPHA,15S-TRIHYDROXY-PROST-13E-EN-1-OIC ACID, also known as prostaglandin E2, is a naturally occurring lipid compound that plays a crucial role in inflammation and immune response in the body. It is derived from arachidonic acid and is produced by various cells in the body, particularly in response to injury or infection. Prostaglandin E2 acts as a signaling molecule, regulating processes such as fever, pain perception, and the dilation of blood vessels. It also has effects on the gastrointestinal tract, reproductive system, and respiratory system. Due to its diverse biological effects, prostaglandin E2 has been studied extensively and is a target for pharmaceutical research in the development of anti-inflammatory and pain-relieving drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 10164-73-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,6 and 4 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 10164-73:
(7*1)+(6*0)+(5*1)+(4*6)+(3*4)+(2*7)+(1*3)=65
65 % 10 = 5
So 10164-73-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18+,19+/m0/s1
10164-73-5Relevant articles and documents
Just et al.
, p. 5364,5368 (1969)
Stereocontrolled Synthesis of Prostaglandins from Cyclopentadiene Monoepoxide
Marino, Joseph P.,Pradilla, Roberto Fernandez de la,Laborde, Edgardo
, p. 5279 - 5280 (2007/10/02)
Two complementary syntheses of prostaglandins from the same key intermediate 3, available in four steps from cyclopentadiene monoepoxide, are described.In one approach, a saturated α-chain is introduced via a 1,4-addition of an appropriately functionalized cyanocuprate reagent onto silyl enol ether 3.The resulting prostanoid compound was converted into the bronchodilator 1-decarboxy-1-hydroxymethyl PGE1, PGE1, and PGF1α.The second approach involves the transformation of silyl enol ether 3 into the known prostanoid precursor 11 via selective addition of carbethoxycarbene and subsequent fluoride-induced ring opening of the resulting (silyloxy)cyclopropane carboxylate ester.
Synthetic studies on prostaglandins.
Holden,Hwang,Williams,Weinstock,Harman,Weisbach
, p. 1569 - 1574 (2007/10/14)
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