101650-08-2

Basic information

• Product Name: (S)-(+)-methyl 2-benzyloxycarbonylaminopentanoate
• Synonyms: (S)-(+)-methyl 2-benzyloxycarbonylaminopentanoate
• CAS NO: 101650-08-2
• Molecular Weight: 265.309
• Mol File: 101650-08-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 395.5±35.0 °C(Predicted)
• Density: 1.117±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (S)-(+)-methyl 2-benzyloxycarbonylaminopentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-methyl 2-benzyloxycarbonylaminopentanoate(101650-08-2)
• EPA Substance Registry System: (S)-(+)-methyl 2-benzyloxycarbonylaminopentanoate(101650-08-2)

Safety Data

• Hazardous Substances Data: 101650-08-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 127862-67-3 N-benzyloxycarbonyl-DL-norvaline 2,2,2-trifluoroethyl ester 
• 21691-44-1 Z-L-norvaline 
• 56558-30-6 methyl L-norvalinate hydrochloride 
• 93712-83-5 L-norvaline methyl ester isocyanate 
• 100-51-6 benzyl alcohol 
• 91230-11-4 (1-vinyl-butyl)-carbamic acid benzyl ester 

Downstream Products

• 21691-44-1 Z-L-norvaline 
• 1416992-32-9 C₂₀H₂₇N₃O₅ 
• 1416992-40-9 C₂₀H₂₈N₃O₈S^(1-)*Na⁽¹⁺⁾ 
• 1416992-25-0 C₂₀H₂₉N₃O₅ 
• 1416992-18-1 C₂₁H₂₉N₃O₆ 
• 145842-50-8 benzyl N-[(1S)-1-(hydroxymethyl)butyl]carbamate 

Relevant articles and documents

2-OXO-1-IMIDAZOLIDINYL IMIDAZOTHIADIAZOLE DERIVATIVES

The present invention relates to 2-oxo-1-imidazolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors

Noroviruses are the most common cause of acute viral gastroenteritis, accounting for >21 million cases annually in the US alone. Norovirus infections constitute an important health problem for which there are no specific antiviral therapeutics or vaccines. In this study, a series of bisulfite adducts derived from representative transition state inhibitors (dipeptidyl aldehydes and α-ketoamides) was synthesized and shown to exhibit anti-norovirus activity in a cell-based replicon system. The ED 50 of the most effective inhibitor was 60 nM. This study demonstrates for the first time the utilization of bisulfite adducts of transition state inhibitors in the inhibition of norovirus 3C-like protease in vitro and in a cell-based replicon system. The approach described herein can be extended to the synthesis of the bisulfite adducts of other classes of transition state inhibitors of serine and cysteine proteases, such as α-ketoheterocycles and α-ketoesters.

Resolution of non-protein amino acids via Carica papaya lipase-catalyzed enantioselective transesterification

Carica papaya lipase-catalyzed transesterification of the 2,2,2-trifluoroethyl esters of N-benzyloxycarbonylated dl-amino acids carrying aliphatic side chains proceeded smoothly and, in almost all the cases, enantiospecifically (E = >200), affording the l-methyl esters and leaving the d-trifluoroethyl esters intact.