1016557-75-7

Upstream product

• 6258-30-6 2-(4-chlorophenyl)-2-methylpropanoic acid 
• 57225-86-2 methyl 2-(4-chlorophenyl)-2-methylpropanoate 

Downstream Products

• 1341205-93-3 4-amino-5-[2-(4-chlorophenyl)propan-2-yl]-4H-[1,2,4]-triazole-3-thiol 
• 1341205-80-8 3-[2-(4-chlorophenyl)propan-2-yl]-6-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1341205-81-9 3-[2-(4-chlorophenyl)propan-2-yl]-6-(2,3,4-trifluorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1341205-82-0 3-[2-(4-chlorophenyl)propan-2-yl]-6-(2-trifluoromethoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1341205-83-1 6-(3,5-bistrifluoromethylphenyl)-3-[2-(4-chlorophenyl)propan-2-yl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1341205-84-2 6-(2-fluoro-4-trifluoromethylphenyl)-3-[2-(4-chlorophenyl)-propan-2-yl][1,2,4]triazolo[3,4-b][1,3,4] thiadiazole 
• 1341205-85-3 3-[2-(4-chlorophenyl)propan-2-yl]-6-(3,4,5-trimethoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1020801-53-9 C₂₇H₂₂Cl₄N₄O₂ 

Relevant academic research and scientific papers

Synthesis, spectral characterization and biological evaluation of a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl)propan-2-yl]-7H-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazines

On account of the reported anticancer activity of triazolothiadiazines, we have synthesized a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl) propan-2-yl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and tested for in-vitro cytotoxicity by trypan blue exclusion and MTT assay. These compounds were also evaluated for their in-vivo anthelmintic activity, as well as in-vitro antimicrobial studies. Amongst the tested compounds, the compound 7j was the most promising cytotoxic agent with IC50 value of 10.54 μM in MCF-7 cells. The compounds 7l and 7q exhibited excellent anthelmintic activity. The compounds 7d, 7f, 7j, 7l, 7o, 7p and 7r showed good antibacterial activity, whereas compounds 7e and 7k exhibited excellent antifungal activity. The structures of newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and LCMS analysis.

Synthesis and biological activities of a novel series of 3,6-disubstituted-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles containing gem-dimethylbenzyl moiety

A novel series of 3,6-disubstituted-1,2,4-triazolo-[3,4-b]-1,3,4- thiadiazoles (6a-r) containing gem-dimethyl benzyl moiety were prepared by the condensation of 4-amino-3-aryl/aralkyl substituted-5-mercapto-1,2,4-triazoles (5a-c) with various fluoro substituted aromatic acids in the presence of POCl3. IR, 1H NMR, 13C NMR, 2D NMR (COSY), and mass spectral data confirmed the structures of all the synthesized compounds. All the compounds were also screened for their antibacterial, antifungal and analgesic activities. Compounds 6b, 6d, 6f, 6g, 6h, 6i, 6m, 6n, 6o, 6p, and 6r exhibited promising antibacterial and compounds 6a, 6d, 6f, 6g, 6h, 6k, 6m, 6o, 6p, and 6q showed significant analgesic activities.

SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS

The present invention relates to sodium channel inhibitors of Formula (I): in which R1, R2, R3, R4, R5, X, Y, and Z are as defined herein, and to their use in the treatment of various disease states,