1341205-84-2

Upstream product

• 1016557-75-7 2-(4-chlorophenyl)-2-methylpropanehydrazide 
• 57225-86-2 methyl 2-(4-chlorophenyl)-2-methylpropanoate 
• 1341205-93-3 4-amino-5-[2-(4-chlorophenyl)propan-2-yl]-4H-[1,2,4]-triazole-3-thiol 
• 115029-24-8 2-fluoro-4-(trifluoromethyl)benzoic acid 

Relevant academic research and scientific papers

Synthesis and biological activities of a novel series of 3,6-disubstituted-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles containing gem-dimethylbenzyl moiety

A novel series of 3,6-disubstituted-1,2,4-triazolo-[3,4-b]-1,3,4- thiadiazoles (6a-r) containing gem-dimethyl benzyl moiety were prepared by the condensation of 4-amino-3-aryl/aralkyl substituted-5-mercapto-1,2,4-triazoles (5a-c) with various fluoro substituted aromatic acids in the presence of POCl3. IR, 1H NMR, 13C NMR, 2D NMR (COSY), and mass spectral data confirmed the structures of all the synthesized compounds. All the compounds were also screened for their antibacterial, antifungal and analgesic activities. Compounds 6b, 6d, 6f, 6g, 6h, 6i, 6m, 6n, 6o, 6p, and 6r exhibited promising antibacterial and compounds 6a, 6d, 6f, 6g, 6h, 6k, 6m, 6o, 6p, and 6q showed significant analgesic activities.