10169-34-3 Usage
Uses
Used in Oncology:
Mitomycin D is used as an antineoplastic agent for the treatment of various types of cancer. It is particularly effective against solid malignancies such as stomach, pancreatic, colorectal, and non-small cell lung cancers. The drug is often used in combination with other chemotherapeutic agents to enhance the overall treatment efficacy and improve patient outcomes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, mitomycin D is used as a key component in the development of novel drug delivery systems. These systems aim to improve the drug's bioavailability, delivery, and therapeutic outcomes by employing various carriers such as organic and metallic nanoparticles. This approach helps to overcome the limitations associated with the conventional administration of mitomycin D, such as its short half-life and potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 10169-34-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,6 and 9 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 10169-34:
(7*1)+(6*0)+(5*1)+(4*6)+(3*9)+(2*3)+(1*4)=73
73 % 10 = 3
So 10169-34-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23)13-7(18(13)2)3-19(15)10(8)11(5)20/h6-7,13,23H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-,18?/m1/s1
10169-34-3Relevant academic research and scientific papers
Synthesis of 9-epi-Mitomycin B: The First Inversion of the C-9 Stereochemistry in Mitomycin B
Kasai, Masaji,Kono, Motomichi,Shirahata, Kunikatsu
, p. 5908 - 5911 (2007/10/02)
9-epi-Mitomycin B (2b) with the same C-9 stereochemistry as mitomycin C(1) was synthesized from mitomycin B (2a) through inversion at the C-9 position. 10-O-Decarbamoylmitomycin D (8a), derived from 2a in two steps, was employed as the substrate for the epimerization.The 10-hydroxymethyl group in 8a was epimerized on treatment with diazabicycloundec-7-ene to afford 8b.Successive transformation performed on the functional groups of 8b gave the desired 2b in four steps.The stereochemistry in 2b was confirmed by conversion of 2b to the known mitomycin F (4).
