1016987-47-5

Basic information

• Product Name: 4-[[tris(propan-2-yl)silyl]oxy]aniline
• Synonyms: 4-[[tris(propan-2-yl)silyl]oxy]aniline
• CAS NO: 1016987-47-5
• Molecular Weight: 265.471
• Mol File: 1016987-47-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-[[tris(propan-2-yl)silyl]oxy]aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[[tris(propan-2-yl)silyl]oxy]aniline(1016987-47-5)
• EPA Substance Registry System: 4-[[tris(propan-2-yl)silyl]oxy]aniline(1016987-47-5)

Safety Data

• Hazardous Substances Data: 1016987-47-5(Hazardous Substances Data)

Upstream product

• 13154-24-0 triisopropylsilyl chloride 
• 194869-13-1 tert-Butyl (4-((triisopropylsilyl)oxy)phenyl)carbamate 
• 100-02-7 4-nitro-phenol 

Downstream Products

• 194869-13-1 tert-Butyl (4-((triisopropylsilyl)oxy)phenyl)carbamate 
• 17658-06-9 4-(2,4,6-triphenylpyridinium-1-yl)-phenolate 
• 1610696-32-6 4-nitro-3-(trifluoromethyl)-N-(4-[[tris(propan-2-yl)silyl]oxy]phenyl)aniline 
• 1610695-13-0 2-(4-[[4-nitro-3-(trifluoromethyl)phenyl]amino]phenoxy)-1-(4-[[5-(trifluoromethyl)-1-benzofuran-2-yl]methyl]piperazin-1-yl)ethan-1-one 
• 1610694-27-3 1-[4-[(5-chloro-2,3-dihydro-1-benzofuran-2-yl)methyl]piperazin-1-yl]-2-(4-[[4-nitro-3-(trifluoromethyl)phenyl]amino]phenoxy)ethan-1-one 
• 127817-81-6 4-[[4-nitro-3-(trifluoromethyl)phenyl]amino]phenol 
• 1421005-58-4 N-(4-(triisopropylsilyloxy)phenyl)pivalamide 
• 123-30-8 4-amino-phenol 

Relevant articles and documents

Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study

The activity of p90 ribosomal S6 kinase 2 (RSK2) has emerged as an attractive target for cancer therapy due to its role in the regulation of diverse cellular processes, such as cell transformation and proliferation. Several pan-RSK inhibitors have been identified with BI-D1870 and the pseudo-analogs LJH685 and LJI308 being the most selective, potent, and frequently used small molecule inhibitors. We designed and synthesized a series of pteridinones and pyrimidines to evaluate the structural features of BI-D1870 that are required for RSK2 inhibition. We have identified inhibitors of RSK2 activity, evaluated their target engagement in cells, and measured their effect on cell viability and cytotoxicity in the MOLM-13 acute myeloid leukemia (AML) cell line. The results of our studies support that RSK2 inhibition can be achieved in MOLM-13 cells without potent cytotoxicity. The structure-activity data from this study will be used as a platform to develop novel RSK2 inhibitors.

From alkylarenes to anilines via site-directed carbon–carbon amination

Anilines are fundamental motifs in various chemical contexts, and are widely used in the industrial production of fine chemicals, polymers, agrochemicals and pharmaceuticals. A recent development for the synthesis of anilines uses the primary amination of C–H bonds in electron-rich arenes. However, there are limitations to this strategy: the amination of electron-deficient arenes remains a challenging task and the amination of electron-rich arenes has a limited control over regioselectivity—the formation of meta-aminated products is especially difficult. Here we report a site-directed C–C bond primary amination of simple and readily available alkylarenes or benzyl alcohols for the direct and efficient preparation of anilines. This chemistry involves a novel C–C bond transformation and offers a versatile protocol for the synthesis of substituted anilines. The use of O2 as an environmentally benign oxidant is demonstrated, and studies on model compounds suggest that this method may also be used for the depolymerization of lignin.

ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES

Imidazophenanthridine ligands and metal complexes are provided. The compounds exhibit improved stability through a linking substitution that links a nitrogen bonded carbon of an imidizole ring to a carbon on the adjacent fused aryl ring. The compounds may be used in organic light emitting devices, particularly as emissive dopants, providing devices with improved efficiency, stability, and manufacturing. In particular, the compounds provided herein may be used in blue devices having high efficiency.