1017-79-4

Upstream product

• 100-16-3 4-nitrophenylhydrazone 
• 78-93-3 butanone 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 21296-94-6 2,3-Dimethyl-5-nitro-1H-indole 
• 74327-13-2 1-ethyl-2,3-bis-(p-nitrophenylhydrazono)propyl acetate 
• 16712-58-6 5-amino-2,3-dimethylindole 
• 1333397-47-9 C₁₇H₁₈N₂ 
• 1374754-54-7 1,2,3-trimethyl-7,9-diphenyl-3H-pyrrolo[3,2-f]quinoline 
• 1374754-55-8 4-(1,2,3-trimethyl-9-phenyl-3H-pyrrolo[3,2-f]quinolin-7-yl)phenyl fluoride 
• 1374754-75-2 9-(4-methoxyphenyl)-1,2,3-trimethyl-7-phenyl-3H-pyrrolo[3,2-f]quinoline 
• 1374754-76-3 4-(4-methoxyphenyl)-7,8,9-trimethyl-2-phenyl-7H-pyrrolo[2,3-h]quinoline 
• 1374754-78-5 8,9-dimethyl-4-(4-methylphenyl)-2-phenyl-7H-pyrrolo[2,3-h]quinoline 
• 1374754-77-4 1,2-dimethyl-9-(4-methylphenyl)-7-phenyl-3H-pyrrolo[3,2-f]quinoline 
• 143797-94-8 1,2,3-trimethyl-1H-indol-5-ylamine 

Relevant academic research and scientific papers

Fast alpha nucleophiles: Structures that undergo rapid hydrazone/oxime formation at neutral pH

Hydrazones and oximes are widely useful structures for conjugate formation in chemistry and biology, but their formation can be slow at neutral pH. Kinetics studies were performed for a range of structurally varied hydrazines, and a surprisingly large variation in reaction rate was observed. Structures that undergo especially rapid reactions were identified, enabling reaction rates that rival orthogonal cycloaddition-based conjugation chemistries.

One-pot synthesis of pyrrolo[3,2-f]-and pyrrolo[2,3-h]quinoline derivatives: Observation of an unexpected mechanistic pathway

One-pot synthesis of pyrrolo[3,2-f]- and pyrrolo[2,3-h]quinolines were obtained starting from substituted 5-aminoindoles, benzaldehydes, and phenylacetylenes in the presence of La(OTf)3 as a catalyst in good yields. The indole moiety in 5-aminoindole is believed to be mainly responsible for the observation of unexpected mechanistic pathway to the formation of pyrrolo[2,3-h]quinoline. Georg Thieme Verlag Stuttgart · New York.