1017-79-4Relevant articles and documents
Fast alpha nucleophiles: Structures that undergo rapid hydrazone/oxime formation at neutral pH
Kool, Eric T.,Crisalli, Pete,Chan, Ke Min
supporting information, p. 1454 - 1457 (2014/04/03)
Hydrazones and oximes are widely useful structures for conjugate formation in chemistry and biology, but their formation can be slow at neutral pH. Kinetics studies were performed for a range of structurally varied hydrazines, and a surprisingly large variation in reaction rate was observed. Structures that undergo especially rapid reactions were identified, enabling reaction rates that rival orthogonal cycloaddition-based conjugation chemistries.