1017572-72-3Relevant academic research and scientific papers
Domino 1,4- And 1,6-Addition Reactions of Ketene Silyl Acetals to Dialkynyl Imines Promoted by Aluminum Chloride: Synthesis of Multifunctionalized β-Lactams
Hachiya, Iwao,Nakamura, Kenta,Hara, Masaya,Sato, Koki,Shimizu, Makoto
, p. 14770 - 14794 (2019/11/13)
Domino 1,4- and 1,6-addition reactions of ketene silyl acetals to dialkynyl imines are disclosed. Aluminum chloride promoted domino 1,4- and 1,6-addition reactions of ketene silyl acetals to dialkynyl imines to give a variety of alkenyl iminocyclobutenones in moderate to good yields. The chemoselective reduction of alkenyl iminocyclobutenones and the subsequent thermal rearrangement of resulting alkenyl aminocyclobutenones in the presence of appropriate amines provided cis or trans multifunctionalized β-lactams in moderate to high yields with good to high diastereoselectivities.
Metal-free synthesis of alkynyl imines using an oxophosphonium-mediated approach at ambient temperatures
Dong, Qing-Li,Liu, Guan-Sai,Zhou, Hai-Bin,Chen, Lin,Yao, Zhu-Jun
, p. 1636 - 1640 (2008/09/18)
A metal-free approach was developed for the mild synthesis of N-aryl α-alkynyl imines from corresponding amide precursors for the first time. The electronic effects of substrates and the reaction mechanisms were investigated and discussed. This newly deve
