1017575-48-2Relevant academic research and scientific papers
Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712
Chen, Helen,Blizzard, Timothy A.,Kim, Seongkon,Wu, Jane,Young, Katherine,Park, Young-Whan,Ogawa, Aimie M.,Raghoobar, Susan,Painter, Ronald E.,Wisniewski, Doug,Hairston, Nichelle,Fitzgerald, Paula,Sharma, Nandini,Scapin, Giovanna,Lu, Jun,Hermes, Jeff,Hammond, Milton L.
scheme or table, p. 4267 - 4270 (2011/08/06)
The bridged monobactam β-lactamase inhibitor MK-8712 (1) effectively inhibits class C β-lactamases. Side chain N-alkylated and ring-opened analogs of 1 were prepared and evaluated for combination with imipenem to overcome class C β-lactamase mediated resi
NOVEL INHIBITORS OF BETA-LACTAMASE
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Page/Page column 44-45, (2008/06/13)
A class of 7-oxo-2,6-diazabicyclo-[3.2.0]-heptane-6-sulfonic acid compounds substituted at the two position of the bicyclic ring with a heterocyclylaminocarbonyl group or a carbocyclylaminocarbonyl group are β-lactamase inhibitors. The compounds and their prodrugs and pharmaceutically acceptable salts are useful in the treatment of bacterial infections in combination with β-lactam antibiotics. In particular, the compounds are suitable for use with β-lactam antibiotics (e.g., imipenem and ceftazidime) against micro-organisms resistant to β-lactam antibiotics due to the presence of the β-lactamases.
