1017575-65-3Relevant academic research and scientific papers
Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712
Chen, Helen,Blizzard, Timothy A.,Kim, Seongkon,Wu, Jane,Young, Katherine,Park, Young-Whan,Ogawa, Aimie M.,Raghoobar, Susan,Painter, Ronald E.,Wisniewski, Doug,Hairston, Nichelle,Fitzgerald, Paula,Sharma, Nandini,Scapin, Giovanna,Lu, Jun,Hermes, Jeff,Hammond, Milton L.
, p. 4267 - 4270 (2011/08/06)
The bridged monobactam β-lactamase inhibitor MK-8712 (1) effectively inhibits class C β-lactamases. Side chain N-alkylated and ring-opened analogs of 1 were prepared and evaluated for combination with imipenem to overcome class C β-lactamase mediated resi
