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Usage

Uses

Used in Organic Chemistry Research:
1-Benzyl-3-(phenylsulfonyl)pyrrolidine is used as a research compound for exploring its chemical properties and potential applications in organic chemistry. Its unique structure, which includes a pyrrolidine ring and a phenylsulfonyl group, makes it a valuable subject for studying reactions and interactions within this scientific field.
Used in Chemical Reactions:
As a pyrrolidine derivative with a sulfone group, 1-Benzyl-3-(phenylsulfonyl)pyrrolidine is used as a reactant in various chemical reactions. Its specific functional groups allow it to participate in a range of organic transformations, contributing to the synthesis of more complex molecules or the modification of existing ones.
Used in Pharmaceutical Development:
Although specific applications may vary and require further research, 1-Benzyl-3-(phenylsulfonyl)pyrrolidine could potentially be used as a building block or intermediate in the development of pharmaceutical compounds. Its unique structure may offer opportunities for the creation of new drugs or the improvement of existing ones, particularly in areas where its organosulfur and pyrrolidine properties can be leveraged.

Upstream product

• 5535-48-8 PVS 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 144964-17-0 N-benzyl-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)methanamine 
• 100-46-9 benzylamine 
• 53215-95-5 N-(trimethylsilylmethyl)benzylamine 

Downstream Products

• 1026-59-1 (rac)-N-benzyl-3-phenylpyrrolidine 

Relevant academic research and scientific papers

Highly Efficient and Diastereoselective Construction of Tricyclic Pyrrolidine-Fused Benzo[b]thiophene 1,1-dioxide Derivatives via 1,3-Dipolar [3?+?2] Cycloaddition

A rapid and highly efficient 1,3-dipolar [3?+?2] cycloaddition of nonstabilized azomethine ylides generated in situ with benzo[b]thiophene 1,1-dioxides as the dipolarophiles has been developed. The efficient method affords tricyclic pyrrolidine-fused benz

Synthesis of 3-nitropyrrolidines via dipolar cycloaddition reactions using a modular flow reactor

The generation and subsequent use of unstabilised azomethine ylides in dipolar cycloaddition reactions within a flow microreactor is demonstrated. The 3-nitropyrrolidines produced were furthermore subjected to chemoselective hydrogenation reactions using

Sequential two-electron oxidation of α,α′-disilylmethylamines to generate non-stabilized azomethine ylide: An ideal approach for the construction of substituted and fused pyrrolidine ring systems

α,α′-Di(trimethylsilylmethyl)amines undergo sequential double desilylation processes, by two-electron oxidation initiated either by photoinduced electron transfer (PET) or Ag(I)F, to produce non-stabilized azomethine ylides efficiently which upon trapping with appropriate dipolarophiles give the corresponding pyrrolidines. Application of this strategy to cyclic analogue for the rapid construction of biologically important 1-azabicyclo[m,3.0]alkane framework is discussed.

A New and Efficient Strategy for Non-stabilized Azomethine Ylide via Photoinduced Electron Transfer (PET) Initiated Sequential Double Desilylation

A practical approach for generating non-stabilized azomethine ylide by PTE initiation is generated.

On the Use of N-amino Ethers as Capped Azomethine Ylide Equivalents

N-amino ethers have been found to act as azomethine ylide equivalents.Treatment of these compounds with lithium fluoride in the presence of a reactive dipolarophile afforded dipolar cycloadducts in high yield.The cycloaddition proceeded with complete stereospecificity with dimethyl fumarate and maleate.This result is consistent with the intermediacy of an azomethine ylide.The reaction of N-benzyl-N-(methoxymethyl)-N-amine afforded several silylated diamines when treated with zinc chloride or cesium fluoride in the absence of trapping agent.This can be attributed to an initial loss of the methoxy group to give a transient iminium ion.This species reacts further with the azomethine ylide or undergoes hydrolysis to give a silylated amine.The cycloaddition behavior of several unsymmetrically substituted azomethine ylide precursors was also examined.Competitive rate studies showed that the cycloaddition is compatible with a HOMO-controlled process.The regiochemistry of the cycloaddition, however, is not easily rationalized by simple FMO considerations and may instead be related to the charge transfer interaction energy of the reaction.