101767-83-3

Basic information

• Product Name: 1-BENZYL-3-(PHENYLSULFONYL)PYRROLIDINE
• Synonyms: 1-BENZYL-3-(PHENYLSULFONYL)PYRROLIDINE;Pyrrolidine, 1-(phenylMethyl)-3-(phenylsulfonyl)-
• CAS NO: 101767-83-3
• Molecular Formula: C₁₇H₁₉NO₂S
• Molecular Weight: 301.4
• Mol File: 101767-83-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 469.6 °C at 760 mmHg
• Flash Point: 237.8 °C
• Appearance: /
• Density: 1.228g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-BENZYL-3-(PHENYLSULFONYL)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-3-(PHENYLSULFONYL)PYRROLIDINE(101767-83-3)
• EPA Substance Registry System: 1-BENZYL-3-(PHENYLSULFONYL)PYRROLIDINE(101767-83-3)

Safety Data

• Hazardous Substances Data: 101767-83-3(Hazardous Substances Data)

Usage

General Description

1-Benzyl-3-(phenylsulfonyl)pyrrolidine is a specialized chemical compound often used in the field of organic chemistry. It falls under the category of organosulfur compounds, which is an individual class of organic compounds that contain sulfur. Being a pyrrolidine derivative, it is a member of compounds containing a pyrrolidine ring, which is a five-membered organic cyclic compound with four carbon atoms and one nitrogen atom. Precise properties can vary, but key attributes of this compound include its molecular formula, structure, and characteristics under different conditions. The compound may be used in various chemical reactions where its sulfone and pyrrolidine properties can be utilized. However, details of its toxicity, specific applications, and handling requirements are typical research information.

Upstream product

• 5535-48-8 PVS 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 144964-17-0 N-benzyl-1-(trimethylsilyl)-N-((trimethylsilyl)methyl)methanamine 
• 100-46-9 benzylamine 
• 53215-95-5 N-(trimethylsilylmethyl)benzylamine 

Downstream Products

• 1026-59-1 (rac)-N-benzyl-3-phenylpyrrolidine 

Relevant articles and documents

Highly Efficient and Diastereoselective Construction of Tricyclic Pyrrolidine-Fused Benzo[b]thiophene 1,1-dioxide Derivatives via 1,3-Dipolar [3?+?2] Cycloaddition

A rapid and highly efficient 1,3-dipolar [3?+?2] cycloaddition of nonstabilized azomethine ylides generated in situ with benzo[b]thiophene 1,1-dioxides as the dipolarophiles has been developed. The efficient method affords tricyclic pyrrolidine-fused benz

Sequential two-electron oxidation of α,α′-disilylmethylamines to generate non-stabilized azomethine ylide: An ideal approach for the construction of substituted and fused pyrrolidine ring systems

α,α′-Di(trimethylsilylmethyl)amines undergo sequential double desilylation processes, by two-electron oxidation initiated either by photoinduced electron transfer (PET) or Ag(I)F, to produce non-stabilized azomethine ylides efficiently which upon trapping with appropriate dipolarophiles give the corresponding pyrrolidines. Application of this strategy to cyclic analogue for the rapid construction of biologically important 1-azabicyclo[m,3.0]alkane framework is discussed.

On the Use of N-amino Ethers as Capped Azomethine Ylide Equivalents

N-amino ethers have been found to act as azomethine ylide equivalents.Treatment of these compounds with lithium fluoride in the presence of a reactive dipolarophile afforded dipolar cycloadducts in high yield.The cycloaddition proceeded with complete stereospecificity with dimethyl fumarate and maleate.This result is consistent with the intermediacy of an azomethine ylide.The reaction of N-benzyl-N-(methoxymethyl)-N-amine afforded several silylated diamines when treated with zinc chloride or cesium fluoride in the absence of trapping agent.This can be attributed to an initial loss of the methoxy group to give a transient iminium ion.This species reacts further with the azomethine ylide or undergoes hydrolysis to give a silylated amine.The cycloaddition behavior of several unsymmetrically substituted azomethine ylide precursors was also examined.Competitive rate studies showed that the cycloaddition is compatible with a HOMO-controlled process.The regiochemistry of the cycloaddition, however, is not easily rationalized by simple FMO considerations and may instead be related to the charge transfer interaction energy of the reaction.