1026-59-1

Basic information

• Product Name: Pyrrolidine, 3-phenyl-1-(phenylmethyl)-
• CAS NO: 1026-59-1
• Molecular Formula: C17H19N
• Molecular Weight: 237.345
• Mol File: 1026-59-1.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 3-phenyl-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 3-phenyl-1-(phenylmethyl)-(1026-59-1)
• EPA Substance Registry System: Pyrrolidine, 3-phenyl-1-(phenylmethyl)-(1026-59-1)

Safety Data

• Hazardous Substances Data: 1026-59-1(Hazardous Substances Data)

Usage

General Description

Pyrrolidine, 3-phenyl-1-(phenylmethyl)- is a chemical compound that belongs to the class of organic compounds known as pyrrolidines. It is a colorless liquid with a molecular formula C17H21N and a molecular weight of 239.353 g/mol. It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a building block for the synthesis of various complex organic compounds. This chemical is known to have a mild odor and is used in various chemical reactions and processes in the pharmaceutical and agrochemical industries.

Upstream product

• 100-42-5 styrene 
• 111184-83-9 N,N-bis<(benzotriazol-1-yl)methyl>benzylamine 
• 591-51-5 phenyllithium 
• 104016-82-2 (3R)-1-benzyl-3-methanesulfonyloxy pyrrolidine 
• 6837-05-4 (+/-)-2-phenyl-1,4-butanediol 
• 100-46-9 benzylamine 
• 101767-83-3 N-benzyl-3-(phenylsulfonyl)pyrrolidine 
• 100-58-3 phenylmagnesium bromide 
• 622-79-7 benzyl azide 
• 16766-63-5 5-phenyl-3,4-dihydro-2H-pyran 
• 42856-57-5 (+/-)-1-benzyl-3-phenylpyrrolidine-2,5-dione 
• 118989-05-2 3-phenyl-N-(1'-hydroxy-2'-butyl)-pyrrolidine 
• 100-39-0 benzyl bromide 
• 118988-99-1 3-phenyl-N-(1'-tert-butoxy-2'-butyl)pyrrolidine 

Downstream Products

• 936-44-7 3-phenylpyrrolidine 
• 228579-02-0 1,1-dioxo-2-[4-(3-phenyl-pyrrolidin-1-yl)-butyl]-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one 

Relevant articles and documents

Boron insertion into alkyl ether bonds via zinc/nickel tandem catalysis

Mild methods to cleave the carbon-oxygen (C?O) bond in alkyl ethers could simplify chemical syntheses through the elaboration of these robust, readily available precursors. Here we report that dibromoboranes react with alkyl ethers in the presence of a nickel catalyst and zinc reductant to insert boron into the C?O bond. Subsequent reactivity can effect oxygen-to-nitrogen substitution or one-carbon homologation of cyclic ethers and more broadly streamline preparation of bioactive compounds. Mechanistic studies reveal a cleavage-then-rebound pathway via zinc/nickel tandem catalysis.

Synthesis of 3-substituted pyrrolidines

A method was developed for the synthesis of derivatives of 3-substituted pyrrolidines from activated alkenes by 1,3-dipolar cycloaddition of unstable 2-benzylazomethylide, generated in situ from N-benzyl-N-(methoxymethyl)-N- (trimethylsilyl)amine. A method was developed for the reduction of 4-(3-pyrrolidyl)pyridine, prepared by the above-mentioned method, to the corresponding derivatives of (3-pyrrolidyl)piperidine with high yields under mild conditions.

Iridium-catalyzed N-heterocyclization of primary amines with diols: N-benzylpiperidine

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