101773-48-2

Upstream product

• 878-00-2 4-formylphenyl acetate 
• 100-63-0 phenylhydrazine 

Downstream Products

• 101773-53-9 (E)-1-(2-p-acetoxybebzylidene-1'-phenylhydrazinyl)-1,2-dibenzoylethylene 
• 29954-08-3 (Z)-1,4-diphenyl-2-(phenylamino)but-2-ene-1,4-dione 
• 101773-59-5 3-(p-acetoxyphenyl)-4,5-dibenzoyl-1-phenylpyrazole 
• 50656-02-5 4-Acetoxybenzoylchloridphenylhydrazon 
• 1262109-78-3 (3aS,6aS)-3-[4-(acetyloxy)phenyl]-5,6a-dihydro-1-phenyl-5-[(1R)-1-phenylethyl]pyrrolo[3,4-c]pyrazole-4,6(1H,3aH)dione 

Relevant academic research and scientific papers

Synthesis and stereochemistry of some novel dihydropyrrolo[3,4-c]pyrazoles

Eleven novel dihydropyrrolo[3,4-c]pyrazole derivatives were obtained by the reaction of chiral (1R)-N-(1-phenylethyl)maleimide and C,N-aryl-substituted nitril-imines. The reaction afforded the cycloadducts as a regioisomeric mixture which can be separable in some cases. The structure and stereochemistry of cycloadducts were assigned on the basis of infrared (IR), 1H and 13C nuclear magnetic resonance (NMR), mass and X-ray spectra, optical rotation measurements, and CHN analyses.

Stereospecific copper(II)-catalyzed tandem ring opening/oxidative alkylation of donor-acceptor cyclopropanes with hydrazones: Synthesis of tetrahydropyridazines

Aerobic copper(II)-catalyzed tandem ring opening and oxidative C-H alkylation of donor-acceptor cyclopropanes with bisaryl hydrazones is accomplished to produce tetrahydropyridazines, in which copper(II) plays dual role as a Lewis acid as well as redox catalyst. The reaction is stereospecific, and optically active cyclopropanes can be reacted with high optical purities (89-98% enantiomeric excess). The substrate scope, functional group tolerance, dual role of the copper(II) catalyst, and the use of air as an oxidant are the important practical features. A product bearing a 3-bromoaryl group can be subjected to Pd-catalyzed Suzuki coupling with boronic acid in high yield.