101784-44-5 Usage
Chemical structure
A complex structure consisting of a piperazine ring with a methyl and two 4-chlorophenyl groups attached.
Usage
Often used as a starting material in the synthesis of various pharmaceutical and agrochemical compounds.
Potential application
Studied for its potential application in the treatment of anxiety and depression due to its ability to modulate neurotransmitter levels in the brain.
Research use
Used in research as a ligand in the study of serotonin receptors.
Anti-tumor potential
Has shown potential as an anti-tumor agent in some studies.
Risks and hazards
Like many chemical compounds, it has potential risks and hazards associated with its handling and use.
Molecular weight
Approximately 377.3 g/mol
Appearance
Typically a solid or crystalline substance
Solubility
Soluble in organic solvents such as ethanol, methanol, and acetone, but may have limited solubility in water.
Stability
Generally stable under normal conditions, but may be sensitive to light, heat, or moisture.
Reactivity
Can react with strong acids, strong bases, or oxidizing agents.
Safety precautions
Proper handling, storage, and disposal are necessary to minimize risks and hazards associated with its use.
Regulatory status
May be subject to regulatory controls depending on the intended use and location.
Environmental impact
Potential environmental impact should be considered, and appropriate disposal methods should be followed to minimize harm to the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 101784-44-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,7,8 and 4 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 101784-44:
(8*1)+(7*0)+(6*1)+(5*7)+(4*8)+(3*4)+(2*4)+(1*4)=105
105 % 10 = 5
So 101784-44-5 is a valid CAS Registry Number.
101784-44-5Relevant academic research and scientific papers
He, Shanshan,Xiao, Jingbo,Dulcey, Andrés E.,Lin, Billy,Rolt, Adam,Hu, Zongyi,Hu, Xin,Wang, Amy Q.,Xu, Xin,Southall, Noel,Ferrer, Marc,Zheng, Wei,Liang, T. Jake,Marugan, Juan J.
, p. 841 - 853 (2016)
Recently, we reported that chlorcyclizine (CCZ, Rac-2), an over-the-counter antihistamine piperazine drug, possesses in vitro and in vivo activity against hepatitis C virus. Here, we describe structure-activity relationship (SAR) efforts that resulted in the optimization of novel chlorcyclizine derivatives as anti-HCV agents. Several compounds exhibited EC50 values below 10 nM against HCV infection, cytotoxicity selectivity indices above 2000, and showed improved in vivo pharmacokinetic properties. The optimized molecules can serve as lead preclinical candidates for the treatment of hepatitis C virus infection and as probes to study hepatitis C virus pathogenesis and host-virus interaction.
