782-08-1

Basic information

• Product Name: 1,1'-(chloromethylene)bis[4-chlorobenzene]
• Synonyms: 1,1'-(chloromethylene)bis[4-chlorobenzene];1,1-bis(4-chlorophenyl)chloromethane;Bis(p-chlorophenyl)chloromethane;4,4'-(Chloromethylene)bis(chlorobenzene);Benzene,1,1'-(chloroMethylene)bis[4-chloro-;4,4'-Dichlorobenzhydrylchloride
• CAS NO: 782-08-1
• Molecular Formula: C₁₃H₉Cl₃
• Molecular Weight: 271.56956
• EINECS: 212-311-0
• Mol File: 782-08-1.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 214-216 °C(Press: 2.5 Torr)
• Appearance: /
• Density: 1.325±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1,1'-(chloromethylene)bis[4-chlorobenzene](CAS DataBase Reference)
• NIST Chemistry Reference: 1,1'-(chloromethylene)bis[4-chlorobenzene](782-08-1)
• EPA Substance Registry System: 1,1'-(chloromethylene)bis[4-chlorobenzene](782-08-1)

Safety Data

• Hazardous Substances Data: 782-08-1(Hazardous Substances Data)

Usage

General Description

1,1'-(chloromethylene)bis[4-chlorobenzene] is a chemical compound. It is a pale yellow solid with a molecular formula of C13H8Cl2 and a molecular weight of 231.11 g/mol. 1,1'-(chloromethylene)bis[4-chlorobenzene] is primarily used as a building block in the production of various organic compounds and has applications in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in the manufacturing of dyes, pigments, and polymers. However, it is important to handle this chemical with care as it is toxic to aquatic life and may cause skin irritation and respiratory problems in humans if not handled properly. Additionally, it is not considered to be readily biodegradable and can persist in the environment, posing potential long-term risks.

Upstream product

• 119-56-2 (4-chlorophenyl)phenylmethanol 
• 4732-69-8 Chloro-oxo-acetic acid 
• 90-97-1 4,4'-dichlorobenzophenone 
• 90-98-2 4,4'-Dichlorobenzophenone 
• 7647-01-0 hydrogenchloride 
• 71-43-2 benzene 
• 101-76-8 4,4'-dichlorodiphenylmethane 

Downstream Products

• 13144-33-7 1,1,2,2-tetrakis(4-chlorophenyl)ethane 
• 123124-74-3 1-[Bis-(4-chloro-phenyl)-methyl]-pyrrolidine 
• 123124-51-6 N-(4,4'-dichlorobenzhydryl)piperidine 
• 102993-59-9 1-[bis-(4-chlorophenyl)methyl]imidazole 
• 99905-01-8 4',4''-Dichloro-3alpha-(diphenylmethoxy)tropane hydrochloride 
• 1000691-95-1 4-(bis(4-chlorophenyl)methyl)piperazin-2-one 
• 101-76-8 4,4'-dichlorodiphenylmethane 
• 221915-05-5 2-[N-[bis-(4-chlorophenyl)methyl]-N-methylamino]ethanol 
• 19793-80-7 1,1-bis(4-chlorophenyl)-propane 
• 102448-91-9 4',4''-Dichloro-3alpha-(diphenylmethoxy)tropane 
• 107866-28-4 2-[Bis-(4-chloro-phenyl)-methyl]-propane-1,3-diol 
• 67469-49-2 1-{2-[Bis-(4-chloro-phenyl)-methoxy]-ethyl}-4-((E)-3-phenyl-allyl)-piperazine; compound with (Z)-but-2-enedioic acid 
• 103294-86-6 2--2H-tetrazole 
• 114055-20-8 1--4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride hydrate 

Relevant articles and documents

Capture of benzhydryl chloride ion pairs by cobalt nitrate

A case is presented where a transition metal salt, Co(NO3)2, intervenes in the solvolysis of benzhydryl chloride, after the rate determining ionization step. This is in contrast to the behavior of other salts which intervene early and promote the ionization reaction. This novel behavior of Co(NO3)2 permits for the first time the detection of two ion pair intermediates in the solvolysis of an alkyl chloride which generates an open carbonium ion.

HETEROCYCLICALKYL DERIVATIVE COMPOUNDS AS SELECTIVE HISTONE DEACETYLASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

The present invention relates to novel heterocyclicalkyl derivatives having histone deacetylase (HDAC) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel heterocyclicalkyl derivatives. The novel heterocyclicalkyl derivatives according to the present invention are selective histone deacetylase (HDAC) inhibitors, and may be effectively used for the treatment of histone deacetylase-mediated diseases, such as cell proliferative diseases, inflammatory diseases, autosomal dominant diseases, genetic metabolic diseases, autoimmune diseases, acute/chronic neurological disease, hypertrophy, heart failure, ocular diseases, or neurodegenerative diseases.

Phosphine functionalized polyphosphazenes: soluble and re-usable polymeric reagents for highly efficient halogenations under Appel conditions

In this paper we present the preparation and application of a novel soluble phosphine functionalized polyphosphazene (poly[3-(diphenylphosphino)propylamino]phosphazene) and investigate its application as a polymeric reagent. Upon chlorination of the pendant phosphine groups, the polymer was found to facilitate the rapid and efficient transformation of alcohols to the corresponding chlorides and bromides under Appel-type conditions. Reaction times followed by 31P NMR spectroscopy are shown to be rapid (several minutes) and the yields for the transformation of alcohols to the corresponding halides are in the range 80–99?%. The facile recovery of the oxidized polymeric agent by precipitation is also described, offering a significant advantage over notoriously difficult to remove small molecule phosphine oxide by-products. Furthermore the regeneration of the reactive phosphine chloride pendant groups is demonstrated, which could be efficiently re-used in a further chlorination reaction. Graphical abstract: [Figure not available: see fulltext.]