101817-20-3

Basic information

• Product Name: Hexanoic acid, 6-[[6-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxohexyl]amino]-, methyl ester
• CAS NO: 101817-20-3
• Molecular Formula: C18H34N2O5
• Molecular Weight: 358.478
• Mol File: 101817-20-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Hexanoic acid, 6-[[6-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxohexyl]amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Hexanoic acid, 6-[[6-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxohexyl]amino]-, methyl ester(101817-20-3)
• EPA Substance Registry System: Hexanoic acid, 6-[[6-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxohexyl]amino]-, methyl ester(101817-20-3)

Safety Data

• Hazardous Substances Data: 101817-20-3(Hazardous Substances Data)

Upstream product

• 2780-89-4 methyl 6-aminohexanoate hydrochloride 
• 6404-29-1 6-(tert-butoxycarbonylamino)hexanoic acid 
• 1926-80-3 methyl 6-aminocaproate hydrochloride 

Downstream Products

• 1430817-66-5 C₆₆H₉₁N₉O₁₂ 
• 1430817-65-4 C₆₀H₈₀N₈O₁₁ 
• 138199-80-1 Z-PrTyr-D-Met-Gly-Phe-εAhx-εAhx-OMe 
• 138199-81-2 Z-iPrTyr-D-Met-Gly-Phe-εAhx-εAhx-OMe 
• 138199-83-4 H-iPrTyr-D-Met-Gly-Phe-εAhx-εAhx-OH 
• 138199-82-3 H-PrTyr-D-Met-Gly-Phe-εAhx-εAhx-OH 
• 138199-75-4 Boc-Gly-Phe-εAhx-εAhx-OMe 
• 138199-74-3 Boc-Phe-εAhx-εAhx-OMe 
• 101817-18-9 H-εAhx-εAhx-Gln-Phe-Phe-Gly-OH*trifluoracetat 
• 101817-03-2 Boc-εAhx-εAhx-Gln-Phe-Phe-Gly-OBzl 

Relevant articles and documents

Synthesis and evaluation of a photoactive probe with a multivalent carbohydrate for capturing carbohydrate-lectin interactions

Lectins are ubiquitous carbohydrate-binding proteins of nonimmune origin that are characterized by their specific recognition of defined monosaccharide or oligosaccharide structures. However, the use of carbohydrates to study lectin has been restricted by the weak binding affinity and noncovalent character of the interaction between carbohydrates and lectin. In this report, we designed and synthesized a multifunctional photoaffinity reagent composed of a trialkyne chain, a masked latent amine group, and a photoreactive 3-trifluoromethyl-3- phenyl-diazirine group in high overall yield. Two well-defined chemistries, Huisgen-Sharpless click chemistry and amide bond coupling, were the key steps for installing the multivalent character and tag in our designed photoaffinity probe. The photolabeling results demonstrated that the designed probe selectively labeled the target lectin, RCA120 (Ricinus communis Agglutinin), in an E. coli lysate and an asialoglycoprotein receptor (ASGP-R) on intact HepG2 cell membranes. Moreover, the probe also enabled the detection of weak protein-protein interactions between RCA120 and ovalbumin (OVA).

SYNTHESIS OF ENKEPHALIN ANALOGS. PART IV. N-ALKYLATED DERIVATIVES

Four new derivatives of enkephalin analogs: H-PrTyr-D-Met-Gly-Phe-εAhx-εAhx-OH (24).H-iPrTyr-D-Met-Gly-Phe-εAhx-εAhx-Oh (25).H-Pr-Tyr-D-Met-Gly-Phe-εAhx-OH (30) and H-iPrTyr-D-Met-Gly-Phe-εAhx-OH (31) have been synthesized and tested for agonistic, antagonistic and analgesic activity.Compound 24 showed a moderate μ agonistic potency and high selectivity.

Synthesis of Cyclic and Cyclically Branched Tachykinine Partial Sequences. Part 3: Synthesis of the cyclo and of Two Ring-Expanded Analogues

The authors describe the synthesis of and of two analogues, the ring of which were expanded by the insertion of 1 or 2 molecules of ε-aminocaproic acid.The cyclopeptides had been tested for their activity as to the smooth musculature.The cyclo- as well as the analogue expanded by ε-aminocaproic acid exhibit a behaviour typically of the partial agonists.