138199-75-4Relevant academic research and scientific papers
SYNTHESIS OF ENKEPHALIN ANALOGS. PART IV. N-ALKYLATED DERIVATIVES
Paruszewski, Ryszard,Matusiak, Roza,Rostafinska-Suchar, Grazyna,Gumulka, Stanislaw,Misterek, Krystyna,Dorociak, Anna
, p. 361 - 368 (2007/10/02)
Four new derivatives of enkephalin analogs: H-PrTyr-D-Met-Gly-Phe-εAhx-εAhx-OH (24).H-iPrTyr-D-Met-Gly-Phe-εAhx-εAhx-Oh (25).H-Pr-Tyr-D-Met-Gly-Phe-εAhx-OH (30) and H-iPrTyr-D-Met-Gly-Phe-εAhx-OH (31) have been synthesized and tested for agonistic, antagonistic and analgesic activity.Compound 24 showed a moderate μ agonistic potency and high selectivity.
