1018332-24-5 Usage
Description
(2R,4R)-4-(((9H-fluoren-9-yl)Methoxy)carbonylaMino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid is a complex organic compound with a unique molecular structure. It is characterized by its chiral centers at the 2R and 4R positions, which play a crucial role in its biological activity and potential applications. (2R,4R)-4-(((9H-fluoren-9-yl)Methoxy)carbonylaMino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid is derived from the pyrrolidine family of cyclic amines and features a fluoren-9-ylmethoxycarbonyl group, a tert-butoxycarbonyl group, and a carboxylic acid functional group. Its structural complexity and functional diversity make it a versatile building block in the synthesis of various biologically active molecules and pharmaceuticals.
Uses
Used in Pharmaceutical Industry:
(2R,4R)-4-(((9H-fluoren-9-yl)Methoxy)carbonylaMino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid is used as a reactant/reagent for the synthetic preparation of KMI-008 peptide derivatives and proline-based peptidomimetic analogs. These compounds are of interest due to their potential activity as BACE1 inhibitors (β-secretase inhibitors), which are targets for the treatment of Alzheimer's disease. The compound's unique structure allows for the development of novel inhibitors with improved potency and selectivity.
Used in Peptide Synthesis:
In the field of peptide synthesis, (2R,4R)-4-(((9H-fluoren-9-yl)Methoxy)carbonylaMino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid serves as a reagent/reactant for the preparation of aminoproline residues. These residues are essential components in the solid-phase synthesis of integrin-binding cyclic peptides. The compound's functional groups facilitate the bromination, azidation, and protection/deprotection protocols required for the synthesis of these bioactive peptides, which have potential applications in various therapeutic areas, including cancer, inflammation, and angiogenesis.
Check Digit Verification of cas no
The CAS Registry Mumber 1018332-24-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,8,3,3 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1018332-24:
(9*1)+(8*0)+(7*1)+(6*8)+(5*3)+(4*3)+(3*2)+(2*2)+(1*4)=105
105 % 10 = 5
So 1018332-24-5 is a valid CAS Registry Number.
1018332-24-5Relevant articles and documents
INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF
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, (2019/02/17)
Provided herein are compounds that inhibit pKal, a serine protease whose activity is responsible for proteolytically cleaving kininogen and generating the potent vasodilator and pro-inflammatory peptide bradykinin, which can lead to painful and debilitating inflammatory attacks (e.g., edema). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating pKal-related diseases and disorders (e.g., edema) with the compounds in a subject, by administering the compounds and/or compositions described herein.
