1018477-41-2Relevant academic research and scientific papers
Synthesis and antitumor activity of combretastatin D-4
Uno, Kanako,Tanabe, Takamasa,Ogamino, Takahisa,Okada, Ryoko,Imoto, Masaya,Nishiyama, Shigeru
, p. 291 - 296 (2008/09/20)
Combretastatin D-4 1 was synthesized using electrochemical dimerization of phenols as the key step. Anodic oxidation of bromochloro-phenol 7 provided the corresponding diaryl ether 8. Manipulation of the two hydroxyl groups differenciated, provided the se
