1018480-66-4

Basic information

• Product Name: C₁₈H₁₆F₃N₃O₂S₂
• CAS NO: 1018480-66-4
• Molecular Weight: 427.471
• Mol File: 1018480-66-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₆F₃N₃O₂S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₆F₃N₃O₂S₂(1018480-66-4)
• EPA Substance Registry System: C₁₈H₁₆F₃N₃O₂S₂(1018480-66-4)

Safety Data

• Hazardous Substances Data: 1018480-66-4(Hazardous Substances Data)

Upstream product

• 30433-91-1 [2-(2-thyenyl)ethyl]amine 
• 1018481-30-5 4-chloro-2-(4-methanesulfonylphenyl)-6-trifluoromethylpyrimidine 

Relevant articles and documents

Novel 2-(4-methylsulfonylphenyl)pyrimidine derivatives as highly potent and specific COX-2 inhibitors

New series of 2-(4-methylsulfonylphenyl) and 2-(4-sulfamoylphenyl)pyrimidines were synthesized and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2). COX-1 and COX-2 inhibitory activity of these compounds was determined using purified enzyme (PE) and human whole blood (HWB) assays. Extensive structure-activity relationship (SAR) work was carried out within these series, and a wide number of potent and specific COX-2 inhibitors were identified (HWB COX-2 IC50 = 2.4-0.3 nM and 80- to 780-fold more selective than rofecoxib).