101865-05-8

Basic information

• Product Name: N-(3,4-dimethoxyphenethyl)-2-(2-oxocyclohexyl)acetamide
• Synonyms: N-(3,4-dimethoxyphenethyl)-2-(2-oxocyclohexyl)acetamide
• CAS NO: 101865-05-8
• Molecular Weight: 319.401
• Mol File: 101865-05-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3,4-dimethoxyphenethyl)-2-(2-oxocyclohexyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,4-dimethoxyphenethyl)-2-(2-oxocyclohexyl)acetamide(101865-05-8)
• EPA Substance Registry System: N-(3,4-dimethoxyphenethyl)-2-(2-oxocyclohexyl)acetamide(101865-05-8)

Safety Data

• Hazardous Substances Data: 101865-05-8(Hazardous Substances Data)

Upstream product

• 1438-96-6 (2-oxocyclohexyl)acetic acid 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 110531-43-6 (1,4-dioxa-spiro[4.5]dec-6-yl)-acetic acid-(3,4-dimethoxy-phenethylamide) 
• 4889-97-8 2-oxocyclohexaneacetic acid ethylene acetal 
• 538-75-0 dicyclohexyl-carbodiimide 

Downstream Products

• 110055-24-8 1-(3,4-dimethoxy-phenethyl)-1,3,3a,4,5,6-hexahydro-indol-2-one 

Relevant articles and documents

Synthesis of 2,6-dioxo-1,2,3,4,5,6-hexahydroindoles by acid-catalyzed cyclization of acetal-protected (2,4-dioxocyclohex-l-yl)acetamides and their transformation into 5,8,9,10-tetrahydro-6H-indolo[2,1-a]isoquinolin-9-ones

Acetal-protected (2,4-dioxocyclohex-1-yl)-acetic acids were prepared by allylation of dilithiated 1,3-cyclohexane-1,3-diones, protection of the carbon-yl groups and oxidation of the alkene moiety. Their reaction with amines afforded the corresponding amides which were transformed, by acid-catalyzed cyclization, into various 2,6-dioxo-1,2,3,4,5,6-hexahy-droindoles. The reaction of the latter with triflic acid resulted in the formation of novel 5,8,9,10-tetrahy-dro-6H-indolo[2,1-a]isoquinolin-9-ones.