1018674-46-8

Basic information

• Product Name: tert-butyl (4-(hydroxymethyl)cyclohexyl)methylcarbamate
• Synonyms: tert-butyl (4-(hydroxymethyl)cyclohexyl)methylcarbamate
• CAS NO: 1018674-46-8
• Molecular Weight: 243.346
• Mol File: 1018674-46-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: tert-butyl (4-(hydroxymethyl)cyclohexyl)methylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (4-(hydroxymethyl)cyclohexyl)methylcarbamate(1018674-46-8)
• EPA Substance Registry System: tert-butyl (4-(hydroxymethyl)cyclohexyl)methylcarbamate(1018674-46-8)

Safety Data

• Hazardous Substances Data: 1018674-46-8(Hazardous Substances Data)

Usage

General Description

Tert-butyl (4-(hydroxymethyl)cyclohexyl)methylcarbamate is a chemical compound used primarily as a pesticide and insecticide. It is derived from carbamate, a class of chemicals known for their ability to control pests by affecting their nervous systems. Tert-butyl (4-(hydroxymethyl)cyclohexyl)methylcarbamate is effective in controlling a wide range of insects, including ants, beetles, and cockroaches. However, due to its potential toxicity to humans and other non-target organisms, its use is regulated in many countries. Proper handling and disposal of products containing this chemical are essential to prevent harm to the environment and human health.

Upstream product

• 1197-17-7 4-aminomethyl-cyclohexanecarboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 162046-58-4 4-(N-tert-butyloxycarbonylaminomethyl)-cyclohexane-1-carboxylic acid 
• 222986-86-9 methyl N-tert-butoxycarbonyltranexamate 
• 1074-62-0 4-(aminomethyl)-cyclohexanemethanol 

Downstream Products

• 1173932-24-5 C₂₀H₃₂N₂O₂ 
• 914645-12-8 (S)-[(4-aminomethyl-cyclohexylmethyl)-amino]-phenyl-acetic acid cyclopentyl ester 
• 914645-15-1 (S)-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-phenyl-acetic acid tert-butyl ester 
• 914645-11-7 (S)-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-phenyl-acetic acid cyclopentyl ester 
• 914645-16-2 (S)-{[4-({[2-(1-isobutoxy-ethoxycarbamoyl)-benzo[b]thiophen-6-ylmethyl]-amino}-methyl)-cyclohexylmethyl]-amino}-phenyl-acetic acid tert-butyl ester 
• 1018811-88-5 cyclopentyl (2S)-({[4-(aminomethyl)cyclohexyl]methyl}amino)(cyclohexyl)acetate 
• 1018811-87-4 cyclopentyl (2S)-{[(4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)methyl]amino}(cyclohexyl)acetate 
• 1018811-89-6 cyclopentyl (2S)-cyclohexyl{[(4-{[(3-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}benzyl)amino]methyl}cyclohexyl)methyl]amino}acetate 
• 180046-56-4 tert-butyl N-[[4-(cyanomethyl)cyclohexyl]methyl]carbamate 
• 180046-90-6 trans 4-(tert-butyloxycarbonylaminoethyl)cyclohexaneacetaldehyde 
• 1378849-38-7 trans-(4-methylaminomethyl-cyclohexyl)-methanol 
• 916210-80-5 trans-4-(N-tert-butoxycarbonylaminomethyl)cyclohexane carboxaldehyde 

Relevant articles and documents

OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES

Disclosed are compounds active towards nuclear receptors, pharmaceutical compositions containing the compounds and use of the compounds in therapy.

HDAC INHIBITORS

Compounds of formula (I) inhibit HDAC activity, wherein A, B and D independently represent =C- or =N-; W is a divalent radical -CH=CH- or CH2CH2-; R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non-natural alpha amino acid; z is 0 or 1; and Y, L1, and X1 are as defined in the claims.

ENZYME INHIBITORS

Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers, wherein R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; R2is the side chain of a natural or non-natural alpha amino acid; Y is a bond, -C(=O)-, -S(=O)2-, -C(=O)O-, -C(O)NR3-, -C(=S)-NR3 , -C(=NH)NR3 or -S(=O)2NR3- wherein R3 is hydrogen or optionally substituted C1-C6 alkyl; L1 is a divalent radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n and p are independently 0 or 1 , Q is (i) an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5 - 13 ring members, or (ii), in the case where both m and p are 0, a divalent radical of formula -X2-Q1- or -Q1-X2- wherein X2 is -O-, S- or NRA- wherein RA is hydrogen or optionally substituted C1-C3 alkyl, and Q1 is an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5 - 13 ring members, AIk1 and AIk2 independently represent optionally substituted divalent C3-C7 cycloalkyl radicals, or optionally substituted straight or branched, C1-C6 alkylene, C2-C6 alkenylene ,or C2-C6 alkynylene radicals which may optionally contain or terminate in an ether (-O-), thioether (-S-) or amino (-NRA-) link wherein RA is hydrogen or optionally substituted C1-C3 alkyl; X1 represents a bond; -C(=O); or -S(=O)2-; -NR4C(=O)-, -C(=O)NR4-, -NR4C(=O)NR5- , -NR4S(=O)2-, or -S(=O)2NR4-wherein R4 and R5 are independently hydrogen or optionally substituted C1-C6 alkyl; z is 0 or 1 ; A represents an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system wherein the radicals R1R2NH-Y-L1-X1-[CH2]Z- and HONHCO-[LINKER]- are attached different ring atoms; and -[Linker]- represents a divalent linker radical linking a ring atom in A with the hydroxamic acid group CONHOH, the length of the linker radical, from the terminal atom linked to the ring atom of A to the terminal atom linked to the hydroxamic acid group, is equivalent to that of an unbranched saturated hydrocarbon chain of from 3-10 carbon atoms.