101877-83-2Relevant academic research and scientific papers
Trypsin-catalyzed one-pot multicomponent synthesis of 4-thiazolidinones
Zheng, Hui,Mei, Yi-Jia,Du, Kui,Shi, Qiao-Yue,Zhang, Peng-Fei
, p. 298 - 301 (2013)
A facile enzymatic one-pot multicomponent synthesis of 4-thiazolidinones was developed. The trypsin from porcine pancreas displayed great catalytic activity to promote the reaction of aldehyde, amine and mercaptoacetic acid with high yields showing a broad substrate specificity in this reaction. This trypsin-catalyzed multicomponent conversion method provided a novel strategy to synthesize thiazolidinones and expanded the application of trypsin in organic synthesis.
A facile and effective procedure for the synthesis of 4-thiazolidinone derivatives using Y(OTf)3 as catalyst
Luo, Juan,Zhong, Zijun,Ji, Hongfu,Chen, Jiayin,Zhao, Jun,Zhang, Furen
, p. 438 - 449 (2016/07/23)
ABSTRACT: A one-pot three-component reaction for the synthesis of 4-thiazolidinone derivatives has been established by reacting readily available and inexpensive starting materials of amines, aldehydes and thioglycolic acid using Y(OTf)3 (5 mol%) as catalyst in tetrahydrofuran. This method is very efficient due to low catalyst loading and mild reaction conditions and provides an efficient and promising synthetic strategy for the construction of the thiazolidinone skeleton.
The first solvent-free, microwave-accelerated, three-component synthesis of thiazolidin-4-ones via one-pot tandem Staudinger/aza-wittig reaction
Shanmugavelan, Poovan,Sathishkumar, Murugan,Nagarajan, Sangaraiah,Ranganathan, Raja,Ponnuswamy, Alagusundaram
, p. 1004 - 1011 (2014/08/05)
An efficient and rapid, solvent-free, microwave-accelerated, one-pot, three-component protocol for thiazolidin-4-ones synthesis from organic azides has been reported for the first time via Staudinger/aza-Wittig reaction. The microwave-accelerated, solvent-free approach overcomes the limitations associated with the prevailing solution phase methodologies. In particular, its novelty is that it eradicates the vital limitation, that is, accumulation of water (byproduct) that is known to affect the yield and rate of the reaction. Thus, a library of thiazolidin-4-ones has been synthesized in short time in excellent yields (92-96%).
An expeditious synthesis of thiazolidinones and tetathiazanones
Rawal, Ravindra K.,Srivastava, Tumul,Haq,Katti
, p. 368 - 369 (2007/10/03)
In the present study, 4-thiazolidinones have been assembled by HBTU mediated three-component reaction of amine, aldehyde and mercapto acid derivatives at room temperature. The final compounds are obtained in excellent yields within 30 minutes.
