1019018-76-8Relevant articles and documents
Design and synthesis of glycolic and mandelic acid derivatives as factor Xa inhibitors
Su, Ting,Wu, Yanhong,Doughan, Brandon,Kane-Maguire, Kim,Marlowe, Charles K,Kanter, James P,Woolfrey, John,Huang, Brian,Wong, Paul,Sinha, Uma,Park, Gary,Malinowski, John,Hollenbach, Stan,Scarborough, Robert M,Zhu, Bing-Yan
, p. 2279 - 2282 (2007/10/03)
A series of glycolic and mandelic acid derivatives was synthesized and investigated for their factor Xa inhibitory activity. These analogues are highly potent and selective inhibitors against fXa. In a rabbit deep vein thrombosis model, compound 26 showed