10191-25-0

Basic information

• Product Name: 3-OxopentanoicAcid
• Synonyms: 3-OxopentanoicAcid;3-Oxopentanoic acid, tech. 85 %;3-Oxovaleric Acid;3-Ketovaleric acid;3-Ketopentanoic Acid;3-Oxo-n-valeric Acid;Propionylacetic Acid;β-Ketopentanoic Acid
• CAS NO: 10191-25-0
• Molecular Formula: C₅H₈O₃
• Molecular Weight: 116.11522
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 10191-25-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 65-66 °C (decomp)(Solv: ethyl ether (60-29-7); hexane (110-54-3))
• Boiling Point: 238.6°C at 760 mmHg
• Flash Point: 112.3°C
• Appearance: /
• Density: 1.129g/cm³
• Vapor Pressure: 0.0143mmHg at 25°C
• Refractive Index: 1.434
• PKA: 3.51±0.32(Predicted)
• CAS DataBase Reference: 3-OxopentanoicAcid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-OxopentanoicAcid(10191-25-0)
• EPA Substance Registry System: 3-OxopentanoicAcid(10191-25-0)

Safety Data

• Hazardous Substances Data: 10191-25-0(Hazardous Substances Data)

Usage

Uses

Urinary metabolite of isoleucine found in patients with methylmalonic and proprionic acidemia.

InChI:InChI=1/C5H8O3/c1-2-4(6)3-5(7)8/h2-3H2,1H3,(H,7,8)

Upstream product

• 42482-20-2 3-hydroxyvaleric acid 
• 2033-24-1 cycl-isopropylidene malonate 
• 802294-64-0 propionic acid 
• 30414-53-0 methyl propanoyl acetate 
• 66696-76-2 5-(1-hydroxypropylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 124-38-9 carbon dioxide 
• 33400-61-2 t-Butyl 3-oxopentanoate 
• 328-50-7 α-ketoglutaric acid 
• 4949-44-4 ethyl propanoylacetate 
• 78-93-3 butanone 

Downstream Products

• 1642594-43-1 C₁₄H₁₈O₄ 
• 100886-24-6 4-methyl-5-oxo-3-phenyl-cyclohex-3-enecarboxylic acid 
• 110062-62-9 2-oxo-butyraldehyde-(4-nitro-phenylhydrazone) 
• 30414-53-0 methyl propanoyl acetate 

Relevant articles and documents

Carboxylation of Ketones Using Triethylamine and Magnesium Halides

Procedures for the carboxylation of ketones with carbon dioxide at atmospheric pressure in the presence of magnesium halides and triethylamine are described.A variety of ketones are converted to the corresponding β-keto acids in satisfactory yields by using magnesium chloride-sodium iodide mixtures in acetonitrile.This carboxylation reaction exhibits little regioselectivity with 2-butanone.

Total synthesis and preliminary antibacterial evaluation of the RNA polymerase inhibitors (±)-myxopyronin A and B

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SYNTHESIS OF BOTH THE ENANTIOMERS OF THE HETEROCYCLIC PHEROMONES ISOLATED FROM THE MALE SWIFT MOTH HEPIALUS HECTA L.

Both the enantiomers of the following three main components of the pheromone blend of the male swift moth Hepialus hecta L. were synthesized in highly optically pure state starting from chiral building blocks of microbial origin: (i) 6-ethyl-2-methyl-2,3-dihydro-4H-pyran-4-one, (ii) 1,8-dimethyl-3-ethyl-2,9-dioxabicyclonon-7-en-6-one and (iii) 1,8-dimethyl-3-ethyl-2,9-dioxabicyclonon-7-ene.

ANTIBACTERIAL AGENTS: SIDECHAIN-FLUORINATED MYXOPYRONIN DERIVATIVES

The invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and G are as described in the specification, as well as compositions comprising a compound of formula I, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

Synthesis of a new pyranoanthocyanin dimer linked through a methyl-methine bridge

Two new anthocyanin-derived compounds corresponding to the ethylpyranomalvidin-3-glucoside and the pyranomalvidin-3-glucoside dimer linked through a methyl-methine bridge were synthesized for the first time and their structure characterized by LC-DAD/MS a