101910-43-4Relevant academic research and scientific papers
Total Synthesis of (+)-MPC1001B
Kurogi, Taichi,Okaya, Shun,Fujiwara, Hideto,Okano, Kentaro,Tokuyama, Hidetoshi
, p. 283 - 287 (2016)
The first total synthesis of an epidithiodiketopiperazine alkaloid, (+)-MPC1001B, was accomplished. This synthesis features a tetra-n-butylammonium fluoride mediated intramolecular aldol reaction for forming the 15-membered macrolactone ring, and the construction of an epidithiodiketopiperazine substructure through a stepwise sulfenylation reaction involving a novel trityl trisulfide (TrSSS)-group transfer.
