1019384-47-4Relevant articles and documents
Efficient and selective palladium-catalysed C-3 urea couplings to 3,5-dichloro-2(1H)-pyrazinones
Belfrage, Anna Karin,Gising, Johan,Svensson, Fredrik,?kerblom, Eva,Sk?ld, Christian,Sandstr?m, Anja
, p. 978 - 986 (2015)
The development of a robust palladium-catalysed urea Narylation protocol to install various ureas at the 3-position of the 2(1H)-pyrazinone scaffold is described. The method involves Pd(OAc)2 in combination with bidentate ligands, xantphos [4,5
Synthesis of a quinolone library from ynones
Ward, Timothy R.,Turunen, Brandon J.,Haack, Torsten,Neuenswander, Benjamin,Shadrick, William,Georg, Gunda I.
experimental part, p. 6494 - 6497 (2011/02/24)
A library of 72 quinolones was synthesized from substituted anthranilic acids, using ynone intermediates. These masked β-dicarbonyl synthons allowed cyclization under milder conditions than previously reported quinolone syntheses.