101960-08-1Relevant articles and documents
Diastereoselective Syntheses of Highly Substituted Methyl Tetrahydrofuran-3-carboxylates by Reactions of γ-Lactols with Silylated Nucleophiles
Brueckner, Christiane,Holzinger, Hiltrud,Reissig, Hans-Ulrich
, p. 2450 - 2456 (2007/10/02)
Hydroxyalkylation of enolates generated from methyl 2-siloxycyclopropanecarboxylates 1 followed by fluoride-induced ring opening gives γ-lactols as key intermediates.Their reduction with triethylsilane / BF3*OEt2 affords methyl tetrahydrofuran-3-carboxyla
Synthesis of Functionalized Furan Derivatives by Hydroxyalkylation of Methyl 2-Siloxycyclopropanecarboxylates
Brueckner, Christiane,Reissig, Hans-Ulrich
, p. 1512 - 1513 (2007/10/02)
A variety of methyl tetrahydrofuran-3-carboxylates (4) or the 5-oxo analogues (6) are available in good overall yield by deprotonation of cyclopropanes (1), addition of carbonyl compounds, ring cleavage, and reductive or oxidative work-up, respectively.