101980-41-0

Basic information

• Product Name: 2-BROMO-1-ISOPROPYL-4-NITROBENZENE
• Synonyms: 2-BROMO-1-ISOPROPYL-4-NITROBENZENE;2-Bromo-4-nitro-1-isopropylbenzene;1-Bromo-2-isopropyl-5-nitrobenzene
• CAS NO: 101980-41-0
• Molecular Formula: C₉H₁₀BrNO₂
• Molecular Weight: 244.09
• Mol File: 101980-41-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 294.3 °C at 760 mmHg
• Flash Point: 131.8 °C
• Appearance: /
• Density: 1.456 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-BROMO-1-ISOPROPYL-4-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-ISOPROPYL-4-NITROBENZENE(101980-41-0)
• EPA Substance Registry System: 2-BROMO-1-ISOPROPYL-4-NITROBENZENE(101980-41-0)

Safety Data

• Hazardous Substances Data: 101980-41-0(Hazardous Substances Data)

Usage

General Description

2-Bromo-1-isopropyl-4-nitrobenzene, also known as PIBNB, is a chemical compound with the molecular formula C9H10BrNO2. It is a yellow crystalline solid that is used as an intermediate in the production of pharmaceuticals and agrochemicals. PIBNB is primarily used in the synthesis of antiviral and anti-inflammatory compounds. It is a versatile building block in organic chemistry, allowing for the creation of a wide range of other chemical compounds. PIBNB is also used in the production of rubber chemicals and antioxidants. It is important to handle PIBNB with care, as it is toxic and can cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 1817-47-6 4-nitrocumene 

Downstream Products

• 1476113-93-5 N-(5-chloro-2-isopropylbenzyl)cyclopropanamine 
• 1445789-88-7 methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-isopropylquinolin-4-yl)amino)-5-cyclopentylbenzoate 
• 1445789-86-5 methyl 3-(7-bromo-3-carbamoyl-6-isopropylquinolin-4-ylamino)-5-cyclopentylbenzoate 
• 1445789-78-5 diethyl 2-((3-bromo-4-isopropylphenylamino)methylene)malonate 
• 1445786-80-0 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-isopropylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid 
• 1147014-94-5 4-{[2-(1-methylethyl)-5-nitrophenyl]ethynyl}-7H-pyrrolo[2,3-d]pyrimidine 
• 112299-61-3 3-bromo-4-isopropylaniline 

Relevant articles and documents

AMINOPYRAZOLE DERIVATIVES

An objective of the present invention is to provide low-molecular-weight compounds that can inhibit Src family kinases. The present invention relates to compounds represented by general formula (I) or pharmacologically acceptable salts thereof. In the formula, Ar1 is optionally substituted C6-10 arylene or 5- to 10-membered heteroarylene, and Ar2 is optionally substituted C6-10 aryl or 5- to 10-membered heteroaryl. R1 and R2 are defined as described in the specification.

CHEMICAL COMPOUNDS

The invention is directed to substituted quinoline derivatives. Specifically, the invention is directed to compounds according to Formula (I): wherein R1, R2, R3; R4; and R5 are defined herein. The compounds of the invention are inhibitors of lactate dehydrogenase A and can be useful in the treatment of cancer and diseases associated with tumor cell metabolism, such as cancer, and more specifically cancers of the breast, colon, prostate and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting lactate dehydrogenase A activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.