112299-61-3

Upstream product

• 101980-41-0 2-bromo-1-isopropyl-4-nitrobenzene 
• 1817-47-6 4-nitrocumene 

Downstream Products

• 1476113-93-5 N-(5-chloro-2-isopropylbenzyl)cyclopropanamine 
• 1445789-78-5 diethyl 2-((3-bromo-4-isopropylphenylamino)methylene)malonate 
• 1445789-88-7 methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-isopropylquinolin-4-yl)amino)-5-cyclopentylbenzoate 
• 1445789-86-5 methyl 3-(7-bromo-3-carbamoyl-6-isopropylquinolin-4-ylamino)-5-cyclopentylbenzoate 
• 1445786-80-0 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-isopropylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid 

Relevant academic research and scientific papers

AMINOPYRAZOLE DERIVATIVES

An objective of the present invention is to provide low-molecular-weight compounds that can inhibit Src family kinases. The present invention relates to compounds represented by general formula (I) or pharmacologically acceptable salts thereof. In the formula, Ar1 is optionally substituted C6-10 arylene or 5- to 10-membered heteroarylene, and Ar2 is optionally substituted C6-10 aryl or 5- to 10-membered heteroaryl. R1 and R2 are defined as described in the specification.

CHEMICAL COMPOUNDS

The invention is directed to substituted quinoline derivatives. Specifically, the invention is directed to compounds according to Formula (I): wherein R1, R2, R3; R4; and R5 are defined herein. The compounds of the invention are inhibitors of lactate dehydrogenase A and can be useful in the treatment of cancer and diseases associated with tumor cell metabolism, such as cancer, and more specifically cancers of the breast, colon, prostate and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting lactate dehydrogenase A activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

PROCESS FOR PREPARING N-(5-CHLORO-2-ISOPROPYLBENZYL)CYCLOPROPANAMINE

The present invention relates to a process for preparing N-(5-chloro-2-isopropylbenzyl)cyclopropanamine by hydrogenation of N-[(5-chloro-2-isopropylphenyl)methylene]cyclopropanamine over specific platinum catalysts.