102005-09-4Relevant academic research and scientific papers
Enantioselective Ruthenium(II)/Xyl-SunPhos/Daipen-Catalyzed hydrogenation of γ-Ketoamides
Zhao, Mengmeng,Li, Wanfang,Li, Xiaoming,Ren, Kai,Tao, Xiaoming,Xie, Xiaomin,Ayad, Tahar,Ratovelomanana-Vidal, Virginie,Zhang, Zhaowuo
, p. 6164 - 6171 (2014/07/21)
A0series of γ-hydroxy amides were synthesized with high ena~tioselectivities (up to 99%) usyng asymmetric hydrogenation of the corresponding γ-ketoamides in the presence of Ru-Xyl-SunPhos-Daipen catalyst providing key building blocks for a variety of natu
Elevation of HDL cholesterol by 4-[(Aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides
-
, (2008/06/13)
Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the “good” cholesterol and as such may be useful for treating diseases such as atherosclerosis. These compounds are represented by the formula wherein: R1, R2, and R3are independently hydrogen, C1-C6alkyl, phenyl or —(CH2)1-6phenyl where phenyl is optionally substituted by halogen, cyano, nitro, C1-C6alkyl, C1-C6alkoxy, trifluoromethyl, C1-C6alkoxycarbonyl, —CO2H or OH; R4and R5are independently hydrogen, C1-C10alkyl, C3-C8cycloalkyl, —(CH2)0-6Ar1where Ar1is phenyl, naphthyl, furanyl, pyridinyl or thenyl and Ar1can be optionally substituted by halogen, cyano, nitro, C1-C6alkyl, phenyl, C1-C6alkoxy, phenoxy, trifluoromethyl, C1-C6alkoxycarbonyl, —CO2H or OH, or R4and R5together with the nitrogen to which R4and R5are attached form a ring containing 4-7 carbon atoms; and Ar is phenyl, naphthyl, furanyl, pyridinyl or thienyl which may be optionally substituted by halogen, cyano, nitro, C1-C6alkyl, C3-C6cycloalkyl, phenyl, C1-C6alkoxy, phenoxy, trifluoromethyl, C1-C6alkoxycarbonyl, —CO2H or OH.
PHOTOCYCLISATION OF KETO-LACTAMS. A NEW SYNTHESIS OF FUNCTIONALIZED 1-AZA-BICYCLO(X.Y.0.)ALKANES
Azzouzi, Assia,Dufour, Monique,Gramain, Jean-Claude,Remuson, Roland
, p. 133 - 148 (2007/10/02)
A series of 1-azabicyclo(x.y.0)alkanes has been synthesized using an intramolecular photoreduction.The methodology consists of a regioselective abstraction of a hydrogen α to the nitrogen of an amide by the triplet T1(n, ?*) of a carbonyl derivative.
